A selection of publications with educational value in
Clinical Respiratory Medicine
Most recently added articles listed first
- The Western Australian Mesothelioma Registry: Analysis of 60 years of cases
(Figure 1 of 10.1111/resp.14648)
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Fraser Brims, Nick de Klerk, Chellan Kumarasamy, Lalitha Menon, Nola Olsen and Peter Franklin (DOI: 10.1111/resp.14648)
onlinelibrary.wiley.com/doi/10.1111/resp.14648/full (April 2024)Comment by Dr Mark Lavercombe:
In this report of a series of almost 2,800 patients reported to the Western Australian Mesothelioma Registry (WAMR) with mesothelioma over a period of 60 years, changes in exposure and survival can be seen over time. In particular, median survival has more than doubled from 156 days in 1960-1979 to 360 days in 2010-2020. Most men with mesothelioma worked in building or construction (31%). Do-it-yourself (DIY) & home renovation activities are the largest identified source of asbestos exposure in women with mesothelioma in this registry, accounting for 22% of cases. Thankfully, the data appears to show a reduction in incident rate ratio for DIY home renovation cases since a peak in 2005-2009.20240304 - Understanding the pathogenesis of engineered stone-associated silicosis: The effect of particle chemistry on the lung cell response
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Chandnee Ramkissoon, Yong Song, Seiha Yen, Katherine Southam, Simone Page, Dino Pisaniello, Sharyn Gaskin, Graeme R Zosky (DOI: 10.1111/resp.14625)
onlinelibrary.wiley.com/doi/10.1111/resp.14625/full (March 2024)Comment by Dr Mark Lavercombe:
This study explores the characteristics of engineered stone dust by analysis of fifty types of resin-based engineered stone, three natural stones and two non-resin-based building materials for their crystalline silica, metals and resin content. The investigators exposed human alveolar epithelial cells and macrophages to dust samples, and linear regression was performed to determine association between stone components and cellular response. The results suggest that crystalline silica content only partially explains macrophage toxicity, suggesting concern about the content of reduced-silica engineered stone products might be warranted.20240214 - Topical antibiotics prophylaxis for infections of indwelling pleural/peritoneal catheters (TAP-IPC): A pilot study
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Estee P M Lau, Sam Faber, Chloe Charlesworth, Sue Morey, Sona Vekaria, Pierre Filion, Aron Chakera, Y C Gary Lee (DOI: 10.1111/resp.14595)
onlinelibrary.wiley.com/doi/10.1111/resp.14595/full (February 2024)Comment by Dr Mark Lavercombe:
Indwelling pleural catheters (IPCs) have become part of the standard of care of malignant pleural effusions, although concerns about potential for IPC-related infections persist. Inspired by guidelines for the management of peritoneal dialysis catheters recommending topical mupirocin application at the catheter site, this study explores whether IPCs are affected by the application of topical mupirocin, and whether this is feasible as part of IPC care. In seven IPCs treated with mupirocin, no concerning structural changes were observed in up to six months of observation. Mupirocin application in patients with IPCs was tolerated well. Further studies to evaluate efficacy in preventing infection will be required.20240103 - Dyspnoea relief as an inherent benefit of high flow nasal cannula therapy: A laboratory randomized trial in healthy humans
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Clara Bianquis, Camille Rolland-Debord, Isabelle Rivals, Thomas Similowski, Capucine Morélot-Panzini (DOI: 10.1111/resp.14580)
onlinelibrary.wiley.com/doi/10.1111/resp.14580/full (January 2024)Comment by Dr Mark Lavercombe:
The researchers in this fascinating study induced dyspnoea using thoracoabdominal loading in 32 healthy adults without respiratory disease and with normal body mass index. High-flow nasal cannulae were used to administer either FiO2 21% or 100%. Visual analogue ratings of dyspnoea were completed, and showed both high-flow therapies were associated with reduction in symptoms, with no difference between FiO2 21% or 100%. There were also reductions in patient reported chest tightness and work/effort sensations. The authors hypothesise that the mechanism was reduction in afferent-reafferent mismatch. Further studies in patients with respiratory disease are recommended.20231207 - Benralizumab and mepolizumab treatment outcomes in two severe asthma clinics
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David Langton, John Politis, Taya Collyer, Su-Wei Khung, Philip Bardin (DOI: 10.1111/resp.14578)
onlinelibrary.wiley.com/doi/10.1111/resp.14578/full (December 2023)Comment by Dr Mark Lavercombe:
Management of patients with severe asthma has dramatically changed in recent decades, and the use of anti-interleukin-5 monoclonal antibodies is recommended in patients with a history of exacerbations and elevated serum eosinophils. In this prospective study, the authors evaluate outcomes for two agents in patients from severe asthma clinics at two tertiary centres between January 2017 and July 2020. Both mepolizumab and benralizumab demonstrated improved Asthma Control Questionnaire scores, increase in forced expiratory volume in one second, reduction in exacerbation frequency and reduction in oral corticosteroid use. Benralizumab appears superior in terms of reduction in exacerbations and increase in FEV1 when compared with mepolizumab, while they had similar rates of non-response and adverse effects.20231113 - Racial and ethnic disparities in antifibrotic therapy in idiopathic pulmonary fibrosis
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Joy Zhao, Joseph Fares, Gautam George, Arlene Maheu, Giorgos Loizidis, Jesse Roman, Daniel Kramer, Michael Li, Ross Summer (DOI: 10.1111/resp.14563)
onlinelibrary.wiley.com/doi/10.1111/resp.14563/full (November 2023)Comment by Dr Mark Lavercombe:
In this analysis of almost 50,000 patients with idiopathic pulmonary fibrosis from the TriNetX US Collaborative Network, the authors defined subgroups based on self-identified race and ethnicity. The results demonstrate a significantly lower rate of anti-fibrotic use in patients who identified as Black when compared with White (6.2% vs 11.4%, p <0.0001), Hispanic (10.8% vs. 20.2%, p <0.0001) and Asian (9.6% vs. 14.7%, p = 0.0006). Hispanic patients had higher usage of anti-fibrotics than Asian patients (21.1% vs. 16.3%, p = 0.012), and no other comparisons were significant. Sub-group analysis for patients over 65 or with lower FVC demonstrated a persistent difference between treatment in Black and White cohorts. These data suggest that patients identifying as Black in the United States are significantly less likely to be treated with anti-fibrotic therapies for IPF and further data is required to determine why.20231009 - Ketogenic diet acutely improves gas exchange and sleep apnoea in obesity hypoventilation syndrome: A non-randomized crossover study
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Adam Osman, Chenjuan Gu, David E Kim, Daisy Duan, Bobbie Barron, Luu V Pham, Vsevolod Y Polotsky, Jonathan C Jun (DOI: 10.1111/resp.14526)
onlinelibrary.wiley.com/doi/10.1111/resp.14526/full (August 2023)Comment by Dr Mark Lavercombe:
This pilot study explores the use of a ketogenic diet in the management of patients with suspected obesity hypoventilation syndrome (OHS). Two weeks of high-fat, low-carbohydrate diet was associated with a reduction in PvCO2 of 3 mmHg; those with PvCO2 > 50 mmHg at baseline achieved a reduction in PvCO2 of 6.4 mmHg. The researchers intend further research using arterial blood gas sampling and a more robust diagnosis of OHS in order to further evaluate a possible role for a ketogenic diet in OHS management.20230706 - Phosphodiesterase 5 inhibitor treatment and survival in interstitial lung disease pulmonary hypertension: A Bayesian retrospective observational cohort study Timothy J W Dawes, Colm McCabe, Konstantinos Dimopoulos, Iain Stewart, Simon Bax, Carl Harries, Chinthaka B Samaranayake, Aleksander Kempny, Philip L Molyneaux, Samuel Seitler, Thomas Semple, Wei Li, Peter M George, Vasileios Kouranos, Felix Chua, Elisabetta A Renzoni, Maria Kokosi, Gisli Jenkins, Athol U Wells, Stephen J Wort, Laura C Price (DOI: 10.1111/resp.14378)
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onlinelibrary.wiley.com/doi/10.1111/resp.14378/full (March 2023)Comment by Dr Mark Lavercombe:
In this retrospective cohort study, physicians at the Royal Brompton Hospital National Pulmonary Hypertension Service report on data collected over 21 years including 128 patients with interstitial lung disease with pulmonary hypertension. Included patients were required to have had right heart catheter study, pulmonary function testing and transthoracic echocardiogram. Patients with connective tissue diseases and other causes of pulmonary hypertension were excluded. In patients treated with PDE5 inhibitors, there was a significant improvement in overall survival independent of other prognostic markers, and this was most striking in those with normal right ventricular function at baseline.20230207 - Thoracic manifestations of IgG4-related disease Romain Muller, Mikael Ebbo, Paul Habert, Laurent Daniel, Antoine Briantais, Pascal Chanez, Jean Yves Gaubert, Nicolas Schleinitz (DOI: 10.1111/resp.14422)
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onlinelibrary.wiley.com/doi/10.1111/resp.14422/full (February 2023)Comment by Dr Mark Lavercombe:
This excellent review article collates the literature on IgG4-related disease and particularly its thoracic manifestations. The authors provide an overview of the pathogenesis which remains poorly understood, as well as the clinical and imaging features and a diagnostic algorithm. The identification of a paravertebral soft band on CT chest is relatively specific, while histology will vary depending on the type of tissue sampled. Corticosteroids and rituximab are shown to be effective therapies, although relapse can occur.20230109 - Increased physical activity reduces sleep disturbances in asthma: A randomized controlled trial Natalia Febrini Passos, Patricia D Freitas, Regina Maria Carvalho-Pinto, Alberto Cukier, Celso R F Carvalho (DOI: 10.1111/resp.14359)
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onlinelibrary.wiley.com/doi/10.1111/resp.14359/full (January 2023)Comment by Dr Mark Lavercombe:
In this randomised controlled trial of a forty-minute behavioural intervention once weekly for eight weeks in stable adult asthma patients, the authors report significant improvement in both asthma- and sleep-related outcomes. The intervention group achieved a substantial increase in their activity levels when compared with controls, with increases in daily step counts and the amount of moderate to vigorous physical activity per week, and reduction in sedentary time. Sleep efficiency and asthma control also improved. exposure to inhaled PM2.5 particles and lung adenocarcinoma is demonstrated, with increased levels of exposure associated with increased malignancy risk. Given the low rate of smoking in adult women in Taiwan (<5%), this data suggests another possible contributor to the development of adenocarcinoma in non-smoking women.20221208 - Ipsilateral and contralateral hemidiaphragm dynamics in symptomatic pleural effusion: The 2nd PLeural Effusion And Symptom Evaluation (PLEASE-2) Study Deirdre B Fitzgerald, Sanjeevan Muruganandan, Carolyn J Peddle-McIntyre, Y C Gary Lee and Bhajan Singh (DOI: 10.1111/resp.14307)
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onlinelibrary.wiley.com/doi/10.1111/resp.14307/full (June 2022)Comment by Dr Mark Lavercombe:
This fascinating paper reports the result of bedside ultrasonographic evaluation of both ipsilateral and contralateral diaphragmatic function in patients presenting with unilateral pleural effusion, before and after pleurocentesis. Contralateral hemidiaphragmatic excursion increased in inverse proportion to ipsilateral hemidiaphragmatic excursion, with subsequent normalisation on both sides after drainage. Improvement in ipsilateral excursion correlated with improvement in dyspnoea. These novel findings suggest the need for further study of ventilatory drive and the mechanics of both hemidiaphragms in the setting of pleural effusion, and their association with dyspnoea.20220912 - The needs and wellbeing of severe asthma and COPD carers: A cross-sectional study
Figure 2 of 10.1111/resp. 14167
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Eleanor C Majellano, Vanessa L Clark, Peter G Gibson, Juliet M Foster, Vanessa M McDonald
onlinelibrary.wiley.com/doi/10.1111/resp.14167/full (Feb 2022)Comment by Dr Mark Lavercombe:
Caring for a patient with chronic medical conditions can be a significant burden for caregivers, and this study examines the degree and nature of those burdens in carers of patients with severe asthma and COPD. Although limited by its relatively homogeneous sample, the authors present important data that illustrate the physical and psychosocial impacts on caregivers. Further, the similarity between the impacts of caregiving in severe asthma when compared with carers of COPD patients suggests a potential unmet need for carers of severe asthma patients.20220202 -
Global Initiative for Asthma Strategy 2021: Executive Summary and Rationale for Key Changes Helen K Reddel, Leonard B Bacharier, Eric D Bateman, Christopher E Brightling, Guy G Brusselle, Roland Buhl, Alvaro A Cruz, Liesbeth Duijts, Jeffrey M Drazen, J Mark FitzGerald, Louise J Fleming, Hiromasa Inoue, Fanny W Ko, Jerry A Krishnan, Mark L Levy, Jiangtao Lin, Kevin Mortimer, Paulo M Pitrez, Aziz Sheikh, Arzu A Yorgancioglu, Louis-Philippe Boulet (DOI: 10.1111/resp.14174)
onlinelibrary.wiley.com/doi/10.1111/resp.14174/full (Jan 2022)20220117 - Laryngeal hypersensitivity and abnormal cough response during mannitol bronchoprovocation challenge Joy Wei-Yan Lee, Tunn Ren Tay, Brigitte M Borg, Neha Sheriff, Anne Vertigan, Michael J Abramson and Mark Hew (DOI: 10.1111/resp.14165)
Figure 2 of 10.1111/resp. 14165
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onlinelibrary.wiley.com/doi/10.1111/resp.14165/full (Jan 2022)Comment by Dr Mark Lavercombe:
Chronic cough presents a difficult diagnostic and management challenge, despite best practice guidelines and multidisciplinary treating teams. In this paper, the authors report on a cohort of patients presenting for mannitol bronchoprovocation testing for a variety of indications. Using the result of the mannitol challenge, cough frequency during testing and responses to the Newcastle.20211222 - Impact of early life exposures on COPD in adulthood: A systematic review and meta-analysis Pengfei Duan, Yao Wang, Rongqing Lin, Yiming Zeng, Chengshui Chen, Li Yang, Minghui Yue, Shan Zhong, Yun Wang, Qingying Zhan (DOI: 10.1111/resp.14144)
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onlinelibrary.wiley.com/doi/10.1111/resp.14144/full (Sep 2021)Comment by Dr Mark Lavercombe:
This systematic review and meta-analysis examines the impact of early life exposures to risk factors and the subsequent development of COPD as an adult. Using 30 studies with almost 800 000 participants, the authors find significant associations between childhood serious respiratory infections, pneumonia and bronchitis, asthma, maternal smoking, low birth weight and childhood maltreatment. This study suggests a potential role for addressing these exposures in children for COPD prevention.20211122 - Impact of COVID-19 pandemic restrictions on the cardio-respiratory health of New Zealanders Sarah M Fairweather, Catherina L Chang, Christopher J Mansell, Eskandarain Shafuddin, Robert J Hancox (DOI: 10.1111/resp.14119)
Figure 1A of 10.1111/resp.14119
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onlinelibrary.wiley.com/doi/10.1111/resp.14119/full (Sep 2021)Comment by Dr Mark Lavercombe:
Many will have suspected that infections other than with the SARS-CoV-2 virus would have reduced during periods of strict contact restrictions, and this paper from New Zealand confirms reductions in infective respiratory admissions, including pneumonia, COPD and asthma during Winter of 2020. Non-infective respiratory diagnoses such as lung cancer, pulmonary embolism and pneumothorax did not decline. Although observational, these data suggest support for measures such as self-isolation when symptomatic with viral respiratory tract infections.20211020 - Long term impact of coal mine fire smoke on lung mechanics in exposed adults Nicolette R Holt BSc, Caroline X Gao BEng, MBiostats, Brigitte M Borg, David Brown, Jonathan C Broder, Jillian Ikin, Annie Makar, Thomas McCrabb, Kris Nilsen, Bruce R Thompson, Michael J Abramson (DOI: 10.1111/resp.14102)
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onlinelibrary.wiley.com/doi/10.1111/resp.14102/full (Sep 2021)Comment by Dr Mark Lavercombe:
The authors of this paper illustrate the use of the forced oscillation technique to evaluate lung mechanics in people exposed to PM2.5 particulate matter after a fire in an open-cut brown coal mine in Hazelwood, Australia. Comparison with local residents who were not exposed to the same air pollution demonstrates more negative respiratory system reactance.20210819 - Prevalence and prognostic impact of physical frailty in Interstitial Lung Disease: A prospective cohort study M A Malik Farooqi, Sachi O’Hoski, Sarah Goodwin, Nima Makhdami, Afia Aziz, Gerard Cox, Joshua Wald, Christopher J Ryerson, Marla K Beauchamp, Nathan Hambly and Martin Kolb (DOI: 10.1111/resp.14066)
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onlinelibrary.wiley.com/doi/10.1111/resp.14066/full (Jul 2021)Comment by Dr Mark Lavercombe:
Frailty is an increasingly recognised prognostic marker in many conditions. Assessment for frailty using a simple five-point scale in this cohort of patients with fibrotic interstitial lung diseases demonstrates that frailty is common and associated with higher mortality, even after adjusting for ILD-GAP score. The authors suggest that frailty is potentially modifiable with pulmonary rehabilitation, although this will require further research.20210622 - Impact of Structured Curriculum with Simulation on Bronchoscopy Wen Ting Siow, Gan‐Liang Tan, Chian‐Min Loo, Kay‐Leong Khoo, Adrian Kee, Augustine Tee, Imran bin Mohamed Noor, Noel Tay, Pyng Lee (DOI: 10.1111/resp.14054)
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onlinelibrary.wiley.com/doi/10.1111/resp.14054/full (Jun 2021)Comment by Dr Mark Lavercombe:
The issues of procedural training and assessment of competence are subject to significant debate with a variety of approaches described. In this paper, the authors demonstrate a significant difference in performance measured using the Bronchoscopy Skills and Tasks Assessment Tool (BSTAT) and several other measures, after a 3-month structured curriculum including weekly simulation and direct supervision. Further work is needed to demonstrate a link to diagnostic yield and patient complications.20180521 - Infection risk in sarcoidosis patients treated with methotrexate compared to azathioprine: A retrospective ‘target trial’ emulated with Swedish real‐world data Marios Rossides; Susanna Kullberg; Daniela Di Giuseppe; Anders Eklund; Johan Grunewald; Johan Askling; Elizabeth V Arkema (DOI: 10.1111/resp.14001)
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onlinelibrary.wiley.com/doi/10.1111/resp.14001/full (Jan 2021)Comment by Dr Mark Lavercombe:
In this paper, the authors apply a retrospective target trial emulation on a large dataset of patients with sarcoidosis from Sweden, to examine the difference in infection rates between those treated with methotrexate and azathioprine for their steroid-sparing effect. Their findings suggest an initial reduction in relative infection risk in those treated with methotrexate, although the difference reduced over time. Prospective data is needed to confirm this finding.20210422 - Risk of cancer incidence in patients with idiopathic pulmonary fibrosis: A nationwide cohort study Hong Yeul Lee, MD; Jinwoo Lee, MD; Chang-Hoon Lee, MD; Kyungdo Han, PhD; Sun Mi Choi, MD (DOI: 10.1111/resp.13911)
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onlinelibrary.wiley.com/doi/10.1111/resp.13911/full (Feb 2021)Comment by Dr Mark Lavercombe:
In this large study of over 100,000 patients in the Korea NHIS, the association between a diagnosis of IPF and malignancy is explored. Overall cancer risk is confirmed to be higher (HR-2), largely driven by a significant excess in lung cancer diagnoses (HR-6).20210120 - Priorities and expectations of patients attending a multidisciplinary interstitial lung disease clinic Anna E B Mclean, Susanne E Webster, Margaret Fry, Edmund M Lau, Peter Corte, Paul J Torzillo, Lauren K Troy, Helen E Jo, Monika Geis, Jessica E Rhodes, Shannon Cleary, Lissa Spencer and Tamera J Corte
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onlinelibrary.wiley.com/doi/10.1111/resp.13913/full (January 2021)Comment by Dr Mark Lavercombe:
This authors describe the functions of a multidisciplinary ILD clinic at a tertiary referral centre, expanding on the accepted role in multidisciplinary diagnosis to provide ongoing access to specialist physicians, nurses and physiotherapists in one setting. The patient perspective is provided by the use of instructive quotes from patient survey responses.20201222 - Opportunities to diagnose fibrotic lung diseases in routine care: A primary care cohort study Mark G Jones, Christopher R Hillyar, Anjan Nibber, Alison Chisholm, Andrew Wilson, Toby M Maher, Alan Kaplan, David Price, Simon Walsh, Luca Richeldi, On Behalf of the Respiratory Effectiveness Group's Interstitial Lung Disease Working Group
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onlinelibrary.wiley.com/doi/10.1111/resp.13836/full (December 2020)Comment by Dr Mark Lavercombe:
This study demonstrates that patients with an eventual diagnosis of interstitial lung disease will utilise more healthcare resources in the years leading to their ILD diagnosis, perhaps suggesting that earlier diagnosis is possible. Recognition of potential ILD can have an important impact on appropriate referral, diagnosis and management options, especially when considering agents that affect disease progression in IPF, or specific treatments for ILD associated with other conditions like CTD.20201118 - Acute effects of e-cigarette vaping on pulmonary function and airway inflammation in healthy individuals and in patients with asthma Serafeim-Chrysovalantis Kotoulas, Athanasia Pataka, Kalliopi Domvri, Dionisios Spyratos, Paraskevi Katsaounou, Konstantinos Porpodis, Evangelia Fouka, Aikaterini Markopoulou, Katalin Passa-Fekete, Ioanna Grigoriou, Theodoros Kontakiotis, Paraskevi Argyropoulou and Despoina Papakosta
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onlinelibrary.wiley.com/doi/10.1111/resp.13806/full (October 2020)Comment by Dr Mark Lavercombe:
The rapid escalation in 'vaping' using electronic nicotine delivery devices has not yet been matched by data demonstrating their safety. In a cohort of asthmatic patients taking regular inhaled corticosteroids, acute markers of airway inflammation and pulmonary function changed within five minutes of e-cigarette vaping and this did not occur in healthy controls. The authors discuss the implications for future research in both healthy subjects and patients with pre-existing obstructive lung diseases.20200917 - Periodic limb movements during sleep and blood pressure changes in sleep apnoea: Data from the European Sleep Apnoea Database Carolina Lombardi; Gianfranco Parati; Davide Soranna; Antonella Zambon; Paweł Sliwinski; Gabriel Roisman; Jean-Louis Pepin; Sophia Schiza; Renata Riha; Pavol Joppa; Ingo Fietze; Jan Hedner; Ludger Grote; the European Sleep Apnoea Database (ESADA) Collaborators (DOI: 10.1111/resp.13760)
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onlinelibrary.wiley.com/doi/10.1111/resp.13760/full (Aug 2020)Comment by Dr Mark Lavercombe:
The association between obstructive sleep apnoea and cardiovascular disease is well recognised. In this paper, the authors explore the role of comorbid elevation of the periodic limb movements in sleep index in a cohort of of patients with obstructive sleep apnoea, and demonstrate a significant elevation in systolic blood pressure, even after accounting for the degree of OSA with multivariate analysis. Further studies - including those utilising 24h BP monitoring - are recommended.20200721 - Effects of E-cigarette E-liquid components on bronchial epithelial cells: Demonstration of dysfunctional efferocytosis Miranda P Ween, Rhys Hamon, Matthew G MacOwan, Leigh Thredgold, Paul R Reynolds and Sandra J Hodge (DOI: 10.1111/resp.13696)
Figure 1 of 10.1111/resp.13696
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onlinelibrary.wiley.com/doi/10.1111/resp.13696/full (May 2020)Comment by Dr Mark Lavercombe:
While the cause of the outbreak of e-cigarette, or vaping, product use associated lung injury (EVALI) in the United States remains under investigation, the broader issue of the long-term safety of vaping remains contentious. This paper contributes to the literature demonstrating abnormalities of human bronchial epithelial cell function associated with e-cigarette use. Further investigation and long-term data will be required.20200527 - Artificial stone-associated silicosis in China: A prospective comparison with natural stone-associated silicosis Na Wu. Changjiang Xue. Shiwen Yu. Qiao Ye
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onlinelibrary.wiley.com/doi/10.1111/resp.13744 (May 2019)Comment by Dr Mark Lavercombe:
In a cohort of 81 patients presenting with silicosis to a single centre in China, artificial stone exposure is associated with shorter latency to disease onset, and more rapid radiologic progression and reduction in lung function, when compared with those exposed to natural stone. This paper further contributes to the data surrounding accelerated silicosis in workers exposed to artificial stone that has been noted in multiple countries in recent years.20190520 - Non-invasive screening using ventilatory gas analysis to distinguish between chronic thromboembolic pulmonary hypertension and pulmonary arterial hypertension Mina Akizuki, Koichiro Sugimura, Tatsuo Aoki, Takaaki Kakihana, Shunsuke Tatebe, Saori Yamamoto, Haruka Sato, Kimio Satoh, Hiroaki Shimokawa and Masahiro Kohzuki (DOI: 10.1111/resp.13618)
Figure 5 of 10.1111/resp. 13618
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onlinelibrary.wiley.com/doi/10.1111/resp.13618/full (Apr 2020)Comment by Dr Mark Lavercombe:
Differentiation of the causes of pulmonary hypertension has become more important with targeted treatments available that can change prognosis. This study demonstrates the potential utility of a simple non-invasive test to differentiate between PH and non-PH, and CTEPH and PAH. Further studies will be required to clarify test performance in other patient groups and to exclude confounders.20200330 - Inter-observer variation in image interpretation and the prognostic importance of non-expansile lung in malignant pleural effusion Geoffrey A Martin, Andrew C Kidd, Selina Tsim, Paul Halford, Anna Bibby, Nick A Maskell and Kevin G Blyth (DOI: 10.1111/resp.13681)
Figure 3 of 10.1111/resp. 13681
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onlinelibrary.wiley.com/doi/10.1111/resp.13681/full (Mar 2020)Comment by Dr Mark Lavercombe:
Non-expansile lung is considered a contraindication to talc slurry pleurodesis in malignant pleural effusion, however inter-observer agreement for diagnosing non-expansile lung on chest radiography is unknown. This study demonstrates poor correlation between experienced observers. Implications for study design and clinical treatment choices are considered.20200218 - Underuse of beta-blockers by patients with COPD and co-morbid acute coronary syndrome: A nationwide follow-up study in New Zealand Lianne Parkin, Joshua Quon, Katrina Sharples, David Barson and Jack Dummer (DOI: 10.1111/resp.13662)
Table 4 of 10.1111/resp-13662
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onlinelibrary.wiley.com/doi/10.1111/resp.13662/full (Feb 2020)Comment by Dr Mark Lavercombe:
In this nationwide study of 83425 patients with COPD, of whom 2637 had one or more acute coronary syndrome events during follow-up, low rates of beta-blocker prescription is found. This finding is especially pronounced in those with very severe COPD despite international guidelines recommending the use of beta-blockers in patients with coronary ischaemia and COPD.20200203 - Composition of airway bacterial community correlates with chest HRCT in adults with bronchiectasis Katherine O’neill, Gisli G Einarsson, Stephen Rowan, Leanne Mcilreavey, Andrew J Lee, John Lawson, Tom Lynch, Alex Horsley, Judy M Bradley, J Stuart Elborn, and Michael M Tunney (DOI: 10.1111/resp.13653)
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onlinelibrary.wiley.com/doi/10.1111/resp.13653/full (Jan 2020)Comment by Dr Mark Lavercombe:
In this study the authors demonstrate associations between sputum bacterial community characteristics and both structural and clinical measures in patients with bronchiectasis. Increase in blood inflammatory markers levels correlated with lower bacterial diversity, while reduced bacterial diversity, richness and evenness were associated with structural abnormalities on HRCT. The authors suggest a potential role for pathogenic bacterial dominance contributing to disease state.20191218 - Increased risk of major adverse cardiac events following the onset of acute exacerbations of COPD Mette Reilev, Anton Pottegard, Jesper Lykkegaard, Jens Søndergaard, Truls S Ingebrigtsen And Jesper Hallas (DOI: 10.1111/resp.13575)
Table 3 of 10.1111/resp.13620
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onlinelibrary.wiley.com/doi/10.1111/resp.13575/full (Dec 2019)Comment by Dr Mark Lavercombe:
Multiple studies have demonstrated an increase in cardiovascular outcomes in patients with COPD, and treatment with cardiac medications in patients with AECOPD has also been investigated. This large study demonstrates that adverse cardiac outcomes are markedly increased in patients with AECOPD, and especially in those who require hospitalisation.20191113 - Nasal high-flow therapy compared with non-invasive ventilation in COPD patients with chronic respiratory failure: A randomized controlled cross-over trial Steven Mckinstry, Joseph Singer, Jan Pieter Baarsma, Mark Weatherall, Richard Beasley and James Fingleton (DOI: 10.1111/resp.13575)
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onlinelibrary.wiley.com/doi/10.1111/resp.13575/full (May 2019)Comment by Dr Mark Lavercombe:
Two papers published in Respirology Issue 24.11 (November 2019) consider the role of Nasal High Flow (NHF) therapy in patients with COPD. In this paper, NHF is compared with NIV (untitrated) in stable COPD patients with chronic hypercapnic respiratory failure. Patients found NHF easier to use and more comfortable, although NIV had more marginally more effect on PtCO2 levels.20191015 - Nasal high flow does not improve exercise tolerance in COPD patients recovering from acute exacerbation: A randomized crossover study Guillaume Prieur, Clement Medrinal, Yann Combret, Elise Dupuis Lozeron, Tristan Bonnevie, Francis-Edouard Gravier, Jean Quieffin, Bouchra Lamia, Jean-Christian Borel and Gregory Reychler (DOI: 10.1111/resp.13664)
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onlinelibrary.wiley.com/doi/10.1111/resp.13664/full (Apr 2018)Comment by Dr Mark Lavercombe:
Two papers published in Respirology Issue 24.11 (November 2019) consider the role of Nasal High Flow (NHF) therapy in patients with COPD. In this paper, addition of NHF with air (or oxygen for those requiring LTOT) during high intensity exercise did not improve endurance during pulmonary rehabilitation. Several potential explanations for discordance with prior studies are considered.20191015 - Real-life effectiveness of inhaler device switch from dry powder inhalers to pressurized metred-dose inhalers in patients with asthma treated with ICS/LABA Hae-Sim Park, Dukyong Yoon, Hyun Young Lee, Ga-Young Ban, Simon Wan Yau Ming, Joanna Ling Zhi Jie, Victoria Carter, Antony Hardjojo, Job F M Van Boven and David B Price (DOI: 10.1111/resp.13559)
Table 4 of 10.1111/resp. 13559
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onlinelibrary.wiley.com/doi/10.1111/resp.13559/full (Oct 2019)Comment by Dr Mark Lavercombe:
Selection of inhaler device is known to affect compliance in asthma patients. This study demonstrates that changing from one format to another can lead to significant improvement in outcomes and is generally accepted by the patients.20190916 - Changes in physical activity during hospital admission for chronic respiratory disease Mark W Orme, Theresa C Harvey-Dunstan, Ismet Boral, Emma J L Chaplin, S Fayyaz Hussain, Mike D L Morgan, Michael C Steiner, Sally J Singh and Neil J Greening
Fig 2 of 10.1111/resp. 13513
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onlinelibrary.wiley.com/doi/10.1111/resp.13513 (July 2019)Comment by Dr Mark Lavercombe:
In a large cohort of patients admitted for acute exacerbation of chronic respiratory disease, the authors demonstrate low overall physical activity levels during the inpatient period with no significant improvement over time. This study also demonstrates little day-to-day variance, potentially allowing future study designs to benefit from shorter activity monitoring periods.20190618 - Development and validation of the COugh Assessment Test (COAT) Hyeon-Kyoung Koo, Ina Jeong, Joo-Hee Kim, Sung-Kyoung Kim, Jong-Wook Shin, So Young Park, Chin Kook Rhee, Eun Young Choi, Ji-Yong Moon, Yee Hyung Kim, Hyun Lee, Hye Seon Kang, Kyung Hoon Min, Jin Woo Kim, Je Hyeong Kim, Sang Haak Lee, Kwang Ha Yoo, Deog Kyeom Kim, Hyoung Kyu Yoon, Dong-Gyu Kim, Hui Jung Kim, Ki-Suck Jung, Seung Hun Jang on behalf of the Cough Study Group of the Korean Academy of Tuberculosis and Respiratory Disease
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onlinelibrary.wiley.com/doi/10.1111/resp.13462 (January 2019)Comment by Dr Mark Lavercombe:
A simple tool to measure chronic cough and its impact on daily life can be useful for ongoing outpatient or clinic assessment of patients with this condition. In this paper, the authors develop and validate a 5-point questionnaire that correlates well with other tools and demonstrates reliability and validity in a Republic of Korean population.20190521 - Bidirectional association between tuberculosis and sarcoidosis Sheng-Huei Wang, Chi-Hsiang Chung, Tsai-Wang Huang, Wen-Chiuan Tsai, Chung-Kan Peng, Kun-Lun Huang, Wann-Cherng Perng, Chih-Feng Chian, Wu-Chien Chien and Chih-Hao Shen
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onlinelibrary.wiley.com/doi/10.1111/resp.13482 (May 2019)Comment by Dr Mark Lavercombe:
This cohort study demonstrates the difficulty of differentiating sarcoidosis and tuberculosis. The diagnosis of tuberculosis within one year of sarcoidosis diagnosis occurred at a significant rate, suggesting the possibility of misdiagnosis. Further, subsequent diagnosis of sarcoidosis in patients treated for tuberculosis is significant after the first year of follow-up.20190423 - High-intensity inspiratory muscle training in bronchiectasis: A randomized controlled trial Ozge Ozalp, Deniz Inal-Ince, Aslihan Cakmak, Ebru Calik-Kutukcu, Melda Saglam, Sema Savci, Naciye Vardar-Yagli, Hülya Arikan, Jale Karakaya and Lütfi Coplu
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onlinelibrary.wiley.com/doi/10.1111/resp.13397 (Mar 2019)Comment by Dr Mark Lavercombe:
This study evaluates the effect of high-intensity inspiratory muscle training in patients with non-cystic fibrosis bronchiectasis. Two of the three weekly sessions were performed in the patients' homes using a threshold loading device. Improvements in shuttle walk distance and respiratory muscle strength and endurance are noted, along with the social dimension of quality of life. Treatment was well tolerated.20190227 - Pulmonary arterial hypertension in a multi-ethnic Asian population: Characteristics, survival and mortality predictors from a 14-year follow-up study Yinghao Lim, Ting-Ting Low, Siew-Pang Chan,Ting Wei Teo, Jin-Hao Justin Jang, Nicole Yip, Ivandito Kuntjoro, Edgar Lik-Wui Tay And James Wei-Luen Yip
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onlinelibrary.wiley.com/doi/10.1111/resp.13392 (Feb 2019)Comment by Dr Mark Lavercombe:
The authors of this paper publish the first data for a multi-ethnic Asian cohort of patients with pulmonary arterial hypertension and have follow-up to 14 years. The REVEAL risk score for prediction of one-year mortality is evaluated with a cut off of >6 found to have a hazard ratio for earlier death of 4.4.20190116 - Risk factors for pleural effusion recurrence in patients with Malignancy Horiana B Grosu, Sofia Molina, Roberto Casal, Juhee Song, Liang Li, Javier Diaz-Mendoza, Chakravarthy Reddy, Lonny Yarmus, Dante Schiavo, Michael Simoff, Jared Johnstun, Abu-Awwad Raid, David Feller-Kopman, Hans Lee, Sarina Sahetya, Finbar Foley, Fabien Maldonado, Xin Tian, Laila Noor, Russell Miller, Lakshmi Mudambi, Timothy Saettele, Macarena Vial-Rodriguez, Gerogie A Eapen and David E Ost (DOI: 10.1111/resp.13362)
Figure 3
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onlinelibrary.wiley.com/doi/10.1111/resp.13362/full (Jan 2019)Comment by Dr Mark Lavercombe:
Although malignant pleural effusion can be treated with repeated thoracenteses, identification of patients more likely to suffer recurrence of their effusion might lead to earlier definitive intervention. The authors identify several risk factors for recurrence in their cohort, however further study is required to develop a predictive model with external validity.20181218 - Metformin is associated with a lower risk of active tuberculosis in patients with type 2 diabetes Shang-Yi Lin, Hung-Pin Tu, Po-Liang Lu, Tun-Chieh Chen, Wen-Hung Wang, Inn-Wen Chong and Yen-Hsu Chen
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onlinelibrary.wiley.com/doi/10.1111/resp.13338 (Nov 2018)Comment by Dr Mark Lavercombe:
This population study examines the incidence of active tuberculosis diagnosis in a large population of patients with Type 2 Diabetes Mellitus. The authors demonstrate a significant protective effect in patients taking metformin, that is not seen with the use of other treatments including oral agents and insulin (despite improved glycaemic control). This suggests protection not only by improved glycaemic control but perhaps also via immune functions of metformin itself.20181016 - Annual Southeast Asia haze increases respiratory admissions: A 2-year large single institution experience Chew R Ming, Andrea Ban Yu-Lin, Mohammad F Abdul Hamid, Mohd T Latiff, Nurashikin Mohammad and Tidi Hassan
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onlinelibrary.wiley.com/doi/10.1111/resp.13325 (Oct 2018)Comment by Dr Mark Lavercombe:
The authors review two years of data from their Malaysian hospital for correlation between respiratory admissions and local haze conditions. The findings demonstrate significantly increased rates of admission with respiratory symptoms during a haze, particularly in those with chronic lung or cardiac disease, and those with obesity. Length of stay and requirement for intensive care also increased in the haze periods.20180926 - Pulmonary infarction secondary to pulmonary embolism: An evolving paradigm Marjan Islam, Jason Filopei, Matthew Frank, Navitha Ramesh, Stacey Verzosa, Madeline Ehrlich, Eric Bondarsky, Albert Miller and David Steiger
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onlinelibrary.wiley.com/doi/10.1111/resp.13299 (Sep 2018)Comment by Dr Mark Lavercombe:
This paper describes the findings of a retrospective review of 367 patients from a single centre who presented with pulmonary embolism. Pulmonary infarction was associated with younger age, absence of cardiopulmonary disease, presence of pleuritic chest pain and presence of an ipsilateral pleural effusion. Explanations based on pulmonary blood flow physiology and the development of collateral supply are proposed.20180823 - S100A12 as a marker of worse cardiac output and mortality in pulmonary hypertension Argyrios Tzouvelekis, Jose D Herazo-Maya, Changwan Ryu, Jen-Hwa Chu, Yingze Zhang, Kevin F Gibson, Percy K Adonteng-Boateng, Qin Li,1 Hongyi Pan, Benjamin Cherry, Ferhaan Ahmad, Hubert J Ford, Erica L Herzog, Naftali Kaminski and Wassim H Fares
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onlinelibrary.wiley.com/doi/10.1111/resp.13302 (Jul 2018)Comment by Dr Mark Lavercombe:
This intriguing study suggests the use of serum SA100A12 concentration as a prognostic marker in pulmonary hypertension. Despite relatively small sample sizes, elevated S100A12 levels were significantly associated with a diagnosis of PH, and negatively correlated to cardiac output. Increased overall mortality was associated with S100A12 levels in both discovery and validation cohorts.20180717 - Pulmonary hypertension in interstitial lung disease: Limitations of echocardiography compared to cardiac catheterization Gregory J Keir, S John Wort, Maria Kokosi, Peter M George, Simon L F Walsh, Joseph Jacob, Laura Price, Simon Bax, Elisabetta A Renzoni, Toby M Maher, Peter Macdonald, David M Hansell and Athol U Wells
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onlinelibrary.wiley.com/doi/10.1111/resp.13250 (Jun 2018)Comment by Dr Mark Lavercombe:
The use of transthoracic echocardiography as a screening tool for pulmonary hypertension in patients with interstitial lung disease is explored in this study, which finds significant numbers of patients are misclassified based on TTE parameters. The possibility of a combined risk assessment using other clinical factors is suggested.20180620 - Likelihood of pulmonary hypertension in patients with idiopathic pulmonary fibrosis and emphysema Joseph Jacob, Brian J Bartholmai, Srinivasan Rajagopalan, Ronald Karwoski, Arjun Nair, Simon L F Walsh, Joseph Barnett, Gary Cross, Eoin P Judge, Maria Kokosi, Elisabetta Renzoni, Toby M Maher and Athol U Wells (DOI: 10.1111/resp.13231)
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onlinelibrary.wiley.com/... (Jun 2018)Comment by Dr Mark Lavercombe:
In this study, the authors seek to define the risks of pulmonary hypertension in patients with combined pulmonary fibrosis and emphysema compared with those with IPF alone. Their conclusion that CPFE is "not greater than the sum of its parts" helps guide prognostication in this patient cohort.20180523 - Exertional hypoxemia is more severe in fibrotic interstitial lung disease than in COPD Jean P Du Plessis, Senan Fernandes, Rakin Jamal, Pat Camp, Kerri Johannson, Michele Schaeffer, Pearce G Wilcox, Jordan A Guenette and Christopher J Ryerson (DOI: 10.1111/resp.13226)
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onlinelibrary.wiley.com/doi/10.1111/resp.13226/full (Apr 2018)Comment by Dr Mark Lavercombe:
Clinicians have long relied on extrapolation of data from COPD studies to inform decision making around oxygen supplementation in patients with other chronic lung diseases. This study demonstrates a difference between patients with fibrotic ILDs and COPD in the degree of exertional oxygen desaturation, raising important questions about the appropriateness of extrapolation.20180320 - Serial chest CT in cryptogenic organizing pneumonia: Evolutional changes and prognostic determinants Man P Chung, Bo D Nam, Kyung S Lee, Joungho Han, Jai S Park, Jung H Hwang, Min J Cha and Tae J Kim (DOI: 10.1111/resp.13188)
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onlinelibrary.wiley.com/doi/10.1111/resp.13188/full (Mar 2018)Comment by Dr Mark Lavercombe:
This paper describes the radiological follow-up of patients treated for cryptogenic organising pneumonia and demonstrates a high proportion of patients have residual radiologic abnormality. Several factors associated with persisting abnormalities are identified, including extent of consolidation and treatment duration.20180215 - Unexpandable lung from pleural disease John T Huggins, Fabien Maldonado, Amit Chopra, Najib Rahman and Richard Light (DOI: 10.1111/resp. 13199)
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onlinelibrary.wiley.com/doi/10.1111/resp.13199/full (Feb 2018)Comment by Dr Mark Lavercombe:
This paper outlines the clinical and pathophysiologic features of the unexpandable lung. The authors demonstrate a clear distinction between chronic 'trapped lung' and the 'lung entrapment' that occurs in active pleural disease states such as malignancy or infection.20180126 - History of pulmonary tuberculosis affects the severity and clinical outcomes of COPD Hye Jung Park, Min Kwang Byun, Hyung Jung Kim, Chul Min Ahn, Deog Kyeom Kim, Yu Il Kim, Jin Young Oh, Hyoung Kyu Yoon, Kwang-Ha Yoo and Ki Suck Jung (DOI: 10.1111/resp.13147)
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onlinelibrary.wiley.com/doi/10.1111/resp.13147/full (Jan 2018)Comment by Dr Mark Lavercombe:
The authors of this paper describe a cohort of patients with COPD who were stratified based on self-report of prior history of tuberculosis infection. Patients who admitted to prior Tb had more severe symptoms of COPD, poorer lung function and more frequent exacerbations. This difference was noted despite a lower prevalence of ongoing smoking in the tuberculosis group.20171208 - Usefulness of a routine endoscopic assessment of laryngeal lesions after lung cancer surgery Alex Fourdrain, Florence De Dominicis, Jules Iquille, Sophie Lafitte, Geoni Merlusca, Alejandro Witte Pfister, Patrick Bagan and Pascal Berna (DOI: 10.1111/resp.13139)
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onlinelibrary.wiley.com/doi/10.1111/resp.13139/full (Jan 2018)Comment by Dr Mark Lavercombe:
Vocal cord dysfunction is not uncommon in patients after lung cancer resection, and this study demonstrates a significant association with poor post-operative outcomes including pneumonia, need for bronchoscopy and re-intubation. The authors recommend routine laryngeal screening within 24h of surgery, although treatment outcomes were not assessed in this study.20171208 - Natural history and clinical characteristics of multiple pulmonary nodules with ground glass opacity: Yuki Sato, DaichI Fujimoto, Takeshi Morimoto, Keiichiro Uehara, Kazuma Nagata, Ichiro Sakanoue, Hiroshi Hamakawa, Yutaka Takahashi, Yukihiro Imai and Keisuke Tomii (DOI: 10.1111/resp.13089)
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onlinelibrary.wiley.com/doi/10.1111/resp.13089/full (Nov 2017)Comment by Dr Mark Lavercombe:
The authors of this paper describe the natural history of single and multiple ground glass nodules (GGN) over a 36 month period. They demonstrate that partly solid and ≥ 10mm size solitary GGN are more likely to progress, while ≥ 10 mm and past history of lung cancer were associated with progression in multiple GGN.20171027 - Spirometry reference values for population aged 7–80 years in China: Jingzhou Zhang, Xiao Hu and Guangliang Shan (DOI: 10.1111/resp.13118)
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onlinelibrary.wiley.com/doi/10.1111/resp.13118/full (Nov 2017)Comment by Dr Mark Lavercombe:
Using data from the China National Health Survey 2012–2015, the authors of this paper propose spirometry prediction equations for a general Chinese population aged 7–80 years. Their equations compare favourably to those developed in more heterogeneous cohorts.20171027 - Endobronchial ultrasound-guided transbronchial needle aspiration: Safe as it sounds: Preyas J Vaidya, Mohammed Munavvar, Joerg D Leuppi, Atul C Mehta & Prashant N Chhajed. (DOI: 10.1111/resp.13094)
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onlinelibrary.wiley.com/doi/10.1111/resp.13094/full (Aug 2017)Comment by Dr Mark Lavercombe:
EBUS-TBNA has rapidly become the standard of care for mediastinal and hilr lymph node sampling. This systematic review outlines the range and frequency of potential complications, as well as the possibility that these reports do not represent the full scale of adverse outcomes.20170820 - Effects of diabetes mellitus on the clinical presentation and treatment response in tuberculosis: Chi C Leung, Wing W Yew, Thomas Y W Mok, Kam S Lau, Chi F Wong, Chi H Chau, Chi K Chan, Kwok C Chang, Greta Tam & Cheuk M. Tam. (DOI: 10.1111/resp.13017)
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onlinelibrary.wiley.com/doi/10.1111/resp.13017/full (Aug 2017)Comment by Dr Mark Lavercombe:
This important study demonstrates that patients with concomitant diabetes mellitus have different clinical features at diagnosis of tuberculosis, higher risk of adverse effects on treatment, slower sputum conversion, and lower treatment success at twelve months. Further data on the effect of diabetic control in patients treated for tuberculosis is required.20170820 - Diagnostic value of endobronchial ultrasound elastography for the differentiation of benign and malignant intrathoracic lymph nodes Potjanee Korrungruang and Viboon Boonsarngsuk (resp. 12832/ RES-15-983.R2)
Qualitative endobronchial ultrasound (EBUS) elastography classification of lymph nodes according to the dominant elastographic colour pattern (Figure 1)
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onlinelibrary.wiley.com/doi/10.1111/resp.12979/full (Jul 2017)Comment by Dr Mark Lavercombe:
The authors of this paper outline the use of EBUS elastography for both qualitative and quantitative assessment of mediastinal lymphadenopathy for the presence of malignancy. Their promising findings suggest the need for further study to better define the elastographic features in both benign and malignant conditions, in order to guide the need for TBNA sampling.20170608 - High-sensitivity cardiac troponin T predicts mortality after hospitalization for community-acquired pneumonia Stefan M T Vestjens, Simone M C Spoorenberg, Ger T Rijkers, Jan C Grutters, Jurrien M ten Berg, Peter G Noordzi, Ewoudt M W van de Garde, Willem Jan W Bos and the Ovidius Study Group. (DOI: 10.1111/resp.12996)
Crude survival based on cardiac troponin T (cTnT) level on admission. (Figure 1)
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onlinelibrary.wiley.com/doi/10.1111/resp.12996/full (Jul 2017)Comment by Dr Mark Lavercombe:
This paper demonstrates a significant relationship between levels of cardiac troponin measured at admission in patients with Community-Acquired Pneumonia and both 30-day and long-term mortality. The combination of Pneumonia Severity Index with Troponin level predicted mortality better than either model alone. These findings suggest cardiac evaluation might be worthwhile in patients with CAP and elevated Troponin.20170608 - Home-based telerehabilitation via real-time videoconferencing improves endurance exercise capacity in patients with COPD: The randomized controlled TeleR Study Ling Ling Y Tsai, Renae J McNamara, Chloe Moddel, Jennifer A Alison, David K McKenzie & Zoe J McKeough 10.1111/resp.12966 (May 2017)
Respiratory telerehabilitation (TeleR) trial team from Sydney
(Click image to enlarge)Despite the clear health benefits in COPD patients, participation in pulmonary rehabilitation is variable with potential barriers including reduced mobility, lack of transport or travel costs. This randomised controlled trial evaluates home-based telerehabilitation compared with usual care and finds improved endurance exercise capacity and self-efficacy in the treatment group. Telerehabilitation might be an alternative option for pulmonary rehabilitation in those unable to attend centralised programmes. Table 3 presents outcomes for special consideration.
20170415 Pulmonary Rehabilitation Guidelines for Australia and New Zealand Jennifer A Alison, Zoe J McKeough, Kylie Johnston, Renae J McNamara, Lissa M Spencer, Sue C Jenkins, Catherine J Hill, Vanessa M McDonald, Peter Frith, Paul Cafarella, Michelle Brooke, Helen L Cameron-Tucker, Sarah Candy, Nola Cecins, Andrew S L Chan, Marita T Dale, Leona M Dowman, Catherine Granger, Simon Halloran, Peter Jung, Annemarie L Lee, Regina Leung, Tamara Matulick, Christian Osadnik, Mary Roberts, James Walsh, Sally Wootton, Anne E Holland, on behalf of the Lung Foundation Australia and the Thoracic Society of Australia and New Zealand 10.1111/resp.13025 (Apr 2017)
The aim of these Guidelines is to provide evidence-based recommendations for the practice of pulmonary rehabilitation (PR) specific to Australian and New Zealand healthcare contexts.
These first-ever pulmonary rehabilitation Guidelines for Australia and New Zealand were launched (24-28 March 2017) at the TSANZSRS Annual Scientific Meeting in Canberra, Australia (24-28 March 2017), and were drawn up following a systematic review of over 275 clinical trials.
The Guidelines recommend that all COPD patients should be offered pulmonary rehabilitation regardless of their disease severity.
See the full Editorial for these important Guidelines at onlinelibrary.wiley.com/doi/10.1111/resp.13039/full
20170329Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease 2017 Report Claus F Vogelmeier, Gerard J Criner, Fernando J Martinez, Antonio Anzueto, Peter J Barnes, Jean Bourbeau, Bartolome R Celli, Rongchang Chen, Marc Decramer, Leonardo M Fabbri, Peter Frith, David M G Halpin, M Victorina López Varela, Masaharu Nishimura, Nicolas Roche, Roberto Rodriguez-Roisin, Don D Sin, Dave Singh, Robert Stockley, Jørgen Vestbo, Jadwiga A Wedzicha and Alvar Agusti 10.1111/resp.13012 (Apr 2017)
This Executive Summary focuses primarily on the revised and novel parts of the document, including:
- the assessment of COPD has been refined to separate the spirometric assessment from symptom evaluation. ABCD groups are now proposed to be derived exclusively from patient symptoms and their history of exacerbations;
- for each of the groups A to D, escalation strategies for pharmacological treatments are proposed;
- the concept of de-escalation of therapy is introduced in the treatment assessment scheme;
- nonpharmacologic therapies are comprehensively presented;
- the importance of comorbid conditions in managing COPD is reviewed.
20170205- Characteristics, incidence and outcome of patients admitted to intensive care because of pulmonary embolism Dario Winterton, Michael Bailey, David Pilcher, Giovanni Landoni & Rinaldo Bellomo DOI: 10.1111/resp.12881
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onlinelibrary.wiley.com/doi/10.1111/resp.12881/full (Feb 2017)Comment by Dr Mark Lavercombe:
This important study describes a large cohort of patients admitted with acute pulmonary embolism to Intensive Care Units across Australia and New Zealand. A subpopulation at very high risk of death is identified (those requiring mechanical ventilation). No improvement in mortality rate over time is seen.20170131 - Prevalence and outcomes of diaphragmatic dysfunction assessed by ultrasound technology during acute exacerbation of COPD: A pilot study Federico Antenora, Riccardo Fantini, Andrea Iattoni, Ivana Castaniere, Antonia Sdanganelli, Francesco Livrieri, Roberto Tonelli, Stefano Zona, Marco Monelli, Enrico M Clini & Alessandro Marchioni DOI: 10.1111/resp.12916
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onlinelibrary.wiley.com/doi/10.1111/resp.12916/full (Feb 2017)Comment by Dr Mark Lavercombe:
The indications for thoracic ultrasonography continue to expand, and this study suggests another indication. Diaphragmatic dysfunction found on ultrasound on admission in patients with acute hypercapnic exacerbations of COPD is identified as a risk factor for failure of NIV, duration of mechanical ventilation and short-term mortality. This non-invasive test might help clinicians identify patients at risk of failing standard care.20170131 - Bronchoscopy assessment of acute respiratory failure in interstitial lung disease Antonella Arcadu & Teng Moua DOI: 10.1111/resp.12909
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onlinelibrary.wiley.com/doi/10.1111/resp.12909/full (Feb 2017)Comment by Dr Mark Lavercombe:
This study examines the utility of bronchoscopy in patients admitted with acute exacerbations of interstitial lung disease. Although a relatively low diagnostic yield is identified, significant potential complications are noted and there is no in-hospital mortality benefit seen in those undergoing the procedure.20170131 - Role of BMI, airflow obstruction, St George's Respiratory Questionnaire and age index in prognostication of Asian COPD. Chan et al. (resp12877/RES-16-062.R2)
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onlinelibrary.wiley.com/doi/10.1111/resp.12877/full (Jan 2017)Comment by Dr Mark Lavercombe:
This study identifies important risk factors for mortality in Asian patients with COPD, and develops a prognosis model that is easy to use. Further validation studies will be required to assess its utility.20161220 - Malignant pleural fluid from mesothelioma has potent biological activities. Cheah et al. (resp.12874/ RES-16-044.R1)
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onlinelibrary.wiley.com/doi/10.1111/resp.12874/full (Jan 2017)Comment by Dr Mark Lavercombe:
This original article suggests that malignant pleural effusion in mesothelioma might not be purely a consequence of the malignancy, but could contribute to its pathobiology. This suggests the possibility of future therapeutic targets in this disease.20161220 - Clinical impact of the interstitial lung disease Multidisciplinary service, Jo et al. DOI: 10.1111/resp.12850
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onlinelibrary.wiley.com/doi/10.1111/resp.12850/full (Jul 2016)Comment by Dr Mark Lavercombe:
This study demonstrates that assessment of the diagnosis and management of interstitial lung diseases by an expert multidisciplinary panel can potentially make a major contribution to patient outcomes. A significant proportion of patients is re-classified after MDT discussion, leading to changes in management. Longer term follow-up of patient outcomes might add weight to the use of MDT discussions.20161021 - Etiology of bronchiectasis in adults: a systematic literature review Gao et al. (resp. 12832/ RES-15-983.R2)
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onlinelibrary.wiley.com/doi/10.1111/resp.12832/full (Jun 2016)Comment by Dr Mark Lavercombe:
This systematic review identifies regional variations in the underlying aetiologies for non-CF bronchiectasis, which is important to consider when evaluating the applicability of the bronchiectasis literature. It also provides an evidence base for the clinical workup of these patients leading to a change in management.20161021 - Clinical impact of the interstitial lung disease Multidisciplinary service, Jo et al. DOI: 10.1111/resp.12850
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onlinelibrary.wiley.com/doi/10.1111/resp.12850/full (Jul 2016)Comment by Dr Mark Lavercombe:
This study demonstrates that assessment of the diagnosis and management of interstitial lung diseases by an expert multidisciplinary panel can potentially make a major contribution to patient outcomes. A significant proportion of patients is re-classified after MDT discussion, leading to changes in management. Longer term follow-up of patient outcomes might add weight to the use of MDT discussions.20161021 - Airway stenting in the management of iatrogenic tracheal injuries: 10-Year experience Tazi-Mezalek et al. DOI: 10.1111/resp.12853
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onlinelibrary.wiley.com/doi/10.1111/resp.12853/full (Jul 2016)Comment by Dr Mark Lavercombe:
This paper describes the experience of managing a very rare complication of endotracheal intubation or tracheostomy, including the nature and anatomical distribution of the injuries. Finally, outcomes using different treatment approaches is discussed.20161021 Usefulness of transcutaneous PCO2 to assess nocturnal hypoventilation in restrictive lung disorders. Georges et al.
onlinelibrary.wiley.com/doi/10.1111/resp.12812/full (May 2016)
(Editorial: onlinelibrary.wiley.com/doi/10.1111/resp.12871/abstract)20160915Need for intensive care in patients admitted for asthma: Red flags from the social history. Moghaddas et al.
onlinelibrary.wiley.com/doi/10.1111/resp.12831/full (Jun 2016)
(Editorial: onlinelibrary.wiley.com/doi/10.1111/resp.12870/abstract)20160915Persistence with inhaled corticosteroids reduces the risk of exacerbation among adults with asthma: A real-world investigation. Corrao et al.
onlinelibrary.wiley.com/doi/10.1111/resp.12791/abstract (Apr 2016)20160819Increasing awareness of sex differences in airway diseases. Raghavan and Jain.
onlinelibrary.wiley.com/doi/10.1111/resp.12702/abstract (Dec 2015)20160819Insulin resistance is associated with skeletal muscle weakness in COPD. Wells et al.
onlinelibrary.wiley.com/doi/10.1111/resp.12716/abstract (Dec 2015)20160819Differences in baseline factors and survival between normocapnia, compensated respiratory acidosis and decompensated respiratory acidosis in COPD exacerbation: A pilot study. Lun et al.
onlinelibrary.wiley.com/doi/10.1111/resp.12652/abstract (Oct 2015)20160819Efficacy and tolerability of budesonide/formoterol added to tiotropium compared with tiotropium alone in patients with severe or very severe COPD: A randomized, multicentre study in East Asia. Lee et al.
onlinelibrary.wiley.com/doi/10.1111/resp.12646/abstract (Sep 2015)20160819Pseudomonas aeruginosa antibiotic resistance in Australian cystic fibrosis centres. Smith et al.
onlinelibrary.wiley.com/doi/10.1111/resp.12714/abstract (Dec 2015)
(FREE access: Editor's Choice; Editorial: onlinelibrary.wiley.com/doi/10.1111/resp.12721/abstract)20160819Effect of long-term treatment with corticosteroids on skeletal muscle strength, functional exercise capacity and health status in patients with interstitial lung disease. Hanada et al.
onlinelibrary.wiley.com/doi/10.1111/resp.12807/abstract (May 2016)
(FREE access: Editor's Choice; Editorial: onlinelibrary.wiley.com/doi/10.1111/resp.12843/abstract)20160819Interstitial lung disease associated with gemcitabine: A Japanese retrospective cohort study. Hamada et al.
onlinelibrary.wiley.com/doi/10.1111/resp.12665/abstract (Nov 2015)20160819Systematic review and meta-analysis of respiratory viral coinfections in children. Lim et al.
onlinelibrary.wiley.com/doi/10.1111/resp.12741/abstract (Feb 2016)20160819Randomized controlled trial of the effect of regular paracetamol on influenza infection. Jefferies et al.
onlinelibrary.wiley.com/doi/10.1111/resp.12685/abstract (Dec 2015)
(FREE access: Editor's Choice; Editorial: onlinelibrary.wiley.com/doi/10.1111/resp.12726/abstract20160819Association of sleep apnoea with chronic kidney disease in a large cohort from Taiwan. Chu et al.
onlinelibrary.wiley.com/doi/10.1111/resp.12739/abstract (Jan 2016)
(FREE access: Editor's Choice; Editorial: onlinelibrary.wiley.com/doi/10.1111/resp.12796/abstract)20160819Impact of effective versus sham continuous positive airway pressure on liver injury in obstructive sleep apnoea: Data from randomized trials. Jullian-Desayes et al.
onlinelibrary.wiley.com/doi/10.1111/resp.12672/abstract (Nov 2015)
(Editorial: onlinelibrary.wiley.com/doi/10.1111/resp.12720/abstract)20160819
