A selection of publications with educational value in
Cell and Molecular Biology
Most recently added articles listed first
- Effects of E-cigarette E-liquid components on bronchial epithelial cells: Demonstration of dysfunctional efferocytosis Miranda P Ween, Rhys Hamon, Matthew G MacOwan, Leigh Thredgold, Paul R Reynolds and Sandra J Hodge (DOI: 10.1111/resp.13696)
Figure 1 of 10.1111/resp.13696
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onlinelibrary.wiley.com/doi/10.1111/resp.13696/full (May 2020)Comment by Dr Mark Lavercombe:
While the cause of the outbreak of e-cigarette, or vaping, product use associated lung injury (EVALI) in the United States remains under investigation, the broader issue of the long-term safety of vaping remains contentious. This paper contributes to the literature demonstrating abnormalities of human bronchial epithelial cell function associated with e-cigarette use. Further investigation and long-term data will be required.20200527 - S100A12 as a marker of worse cardiac output and mortality in pulmonary hypertension Argyrios Tzouvelekis, Jose D Herazo-Maya, Changwan Ryu, Jen-Hwa Chu, Yingze Zhang, Kevin F Gibson, Percy K Adonteng-Boateng, Qin Li,1 Hongyi Pan, Benjamin Cherry, Ferhaan Ahmad, Hubert J Ford, Erica L Herzog, Naftali Kaminski and Wassim H Fares
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onlinelibrary.wiley.com/doi/10.1111/resp.13302 (Jul 2018)Comment by Dr Mark Lavercombe:
This intriguing study suggests the use of serum SA100A12 concentration as a prognostic marker in pulmonary hypertension. Despite relatively small sample sizes, elevated S100A12 levels were significantly associated with a diagnosis of PH, and negatively correlated to cardiac output. Increased overall mortality was associated with S100A12 levels in both discovery and validation cohorts.20180717 - Nasopharyngeal viral PCR in immunosuppressed patients and its association with virus detection in bronchoalveolar lavage by PCR: Daniel J Lachant, Daniel P Croft, Heather Mcgrane Minton, Paritosh Prasad & Robert M Kottmann. (DOI: 10.1111/resp.13049)
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onlinelibrary.wiley.com/doi/10.1111/resp.13049/full (Aug 2017)Comment by Dr Mark Lavercombe:
Bronchoscopy with bronchoalveolar lavage is often required for immunosuppressed patients presenting with lung infiltrates. This study compares the diagnostic yield for respiratory virus PCR on nasopharyngeal and BAL specimens, and demonstrates both high concordance and low false negative rate for nasopharyngeal specimens.20170820 - High-sensitivity cardiac troponin T predicts mortality after hospitalization for community-acquired pneumonia Stefan M T Vestjens, Simone M C Spoorenberg, Ger T Rijkers, Jan C Grutters, Jurrien M ten Berg, Peter G Noordzi, Ewoudt M W van de Garde, Willem Jan W Bos and the Ovidius Study Group. (DOI: 10.1111/resp.12996)
Crude survival based on cardiac troponin T (cTnT) level on admission. (Figure 1)
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onlinelibrary.wiley.com/doi/10.1111/resp.12996/full (Jul 2017)Comment by Dr Mark Lavercombe:
This paper demonstrates a significant relationship between levels of cardiac troponin measured at admission in patients with Community-Acquired Pneumonia and both 30-day and long-term mortality. The combination of Pneumonia Severity Index with Troponin level predicted mortality better than either model alone. These findings suggest cardiac evaluation might be worthwhile in patients with CAP and elevated Troponin.20170608 Unproven Stem Cell Treatments for Lung Disease – An Emerging Public Health Problem
Laertis Ikonomou, Angela Panoskaltsis-Mortari, Darcy E Wagner, Robert J Freishtat, Daniel J Weiss, on behalf of the American Thoracic Society Respiratory Cell and Molecular Biology Assembly Stem Cell Working Group. Reviewer: Marianna Sockrider
American Journal of Respiratory and Critical Care Medicine (AJRCCM), 195(7), pp. P13–P14 www.atsjournals.org/doi/10.1164/rccm.1957P13 (Apr 2017)Comment by Dr Yasuhiro Yamauchi:
This piece describes the information about unproven stem cell treatments for lung disease. It was prepared by the ATS Stem Cell Working Group. This would be a good resource for patients considering stem cell treatments for respiratory diseases.20170404- Malignant pleural fluid from mesothelioma has potent biological activities. Cheah et al. (resp.12874/ RES-16-044.R1)
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onlinelibrary.wiley.com/doi/10.1111/resp.12874/full (Jan 2017)Comment by Dr Mark Lavercombe:
This original article suggests that malignant pleural effusion in mesothelioma might not be purely a consequence of the malignancy, but could contribute to its pathobiology. This suggests the possibility of future therapeutic targets in this disease.20161220 The Global Emergence of Unregulated Stem Cell Treatments for Respiratory Diseases
www.atsjournals.org/doi/full/10.1513/AnnalsATS.201604-277ED#.V7ay8vl96Uk (Aug 2016)20160819
