A selection of publications with educational value in
Tuberculosis

Most recently added articles listed first

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  Bidirectional association between tuberculosis and sarcoidosis Sheng-Huei Wang, Chi-Hsiang Chung, Tsai-Wang Huang, Wen-Chiuan Tsai, Chung-Kan Peng, Kun-Lun Huang, Wann-Cherng Perng, Chih-Feng Chian, Wu-Chien Chien and Chih-Hao Shen
  onlinelibrary.wiley.com/doi/10.1111/resp.13482 (May 2019)

  Comment by Dr Mark Lavercombe:
  This cohort study demonstrates the difficulty of differentiating sarcoidosis and tuberculosis. The diagnosis of tuberculosis within one year of sarcoidosis diagnosis occurred at a significant rate, suggesting the possibility of misdiagnosis. Further, subsequent diagnosis of sarcoidosis in patients treated for tuberculosis is significant after the first year of follow-up.

  20190423
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  Metformin is associated with a lower risk of active tuberculosis in patients with type 2 diabetes Shang-Yi Lin, Hung-Pin Tu, Po-Liang Lu, Tun-Chieh Chen, Wen-Hung Wang, Inn-Wen Chong and Yen-Hsu Chen
  onlinelibrary.wiley.com/doi/10.1111/resp.13338 (Nov 2018)

  Comment by Dr Mark Lavercombe:
  This population study examines the incidence of active tuberculosis diagnosis in a large population of patients with Type 2 Diabetes Mellitus. The authors demonstrate a significant protective effect in patients taking metformin, that is not seen with the use of other treatments including oral agents and insulin (despite improved glycaemic control). This suggests protection not only by improved glycaemic control but perhaps also via immune functions of metformin itself.

  20181016
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  Table 1
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  Unexpandable lung from pleural disease John T Huggins, Fabien Maldonado, Amit Chopra, Najib Rahman and Richard Light (DOI: 10.1111/resp. 13199)
  onlinelibrary.wiley.com/doi/10.1111/resp.13199/full (Feb 2018)

  Comment by Dr Mark Lavercombe:
  This paper outlines the clinical and pathophysiologic features of the unexpandable lung. The authors demonstrate a clear distinction between chronic 'trapped lung' and the 'lung entrapment' that occurs in active pleural disease states such as malignancy or infection.

  20180126
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  History of pulmonary tuberculosis affects the severity and clinical outcomes of COPD Hye Jung Park, Min Kwang Byun, Hyung Jung Kim, Chul Min Ahn, Deog Kyeom Kim, Yu Il Kim, Jin Young Oh, Hyoung Kyu Yoon, Kwang-Ha Yoo and Ki Suck Jung (DOI: 10.1111/resp.13147)
  onlinelibrary.wiley.com/doi/10.1111/resp.13147/full (Jan 2018)

  Comment by Dr Mark Lavercombe:
  The authors of this paper describe a cohort of patients with COPD who were stratified based on self-report of prior history of tuberculosis infection. Patients who admitted to prior Tb had more severe symptoms of COPD, poorer lung function and more frequent exacerbations. This difference was noted despite a lower prevalence of ongoing smoking in the tuberculosis group.

  20171208
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  Tuberculosis in China: A longitudinal predictive model of the general population and recommendations for achieving WHO goals: Kaijin Xu, Cheng Ding, Connor J Mangan, Yiping Li, Jingjing Ren, Shigui Yang, Bing Wang, Bing Ruan, Jifang Sheng & Lanjuan Li.
  10.1111/resp.13066 (Oct 2017)

  Comment by Dr Mark Lavercombe:
  By using a Markov chain model, the authors of this study estimate likely future tuberculosis prevalence in China and the impact of various interventions. Their combined intervention model suggests a significant reduction in tuberculosis prevalence is achievable, and barriers to implementation are explored.

  20170920
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  Table 2
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  Effects of diabetes mellitus on the clinical presentation and treatment response in tuberculosis: Chi C Leung, Wing W Yew, Thomas Y W Mok, Kam S Lau, Chi F Wong, Chi H Chau, Chi K Chan, Kwok C Chang, Greta Tam & Cheuk M. Tam. (DOI: 10.1111/resp.13017)
  onlinelibrary.wiley.com/doi/10.1111/resp.13017/full (Aug 2017)

  Comment by Dr Mark Lavercombe:
  This important study demonstrates that patients with concomitant diabetes mellitus have different clinical features at diagnosis of tuberculosis, higher risk of adverse effects on treatment, slower sputum conversion, and lower treatment success at twelve months. Further data on the effect of diabetic control in patients treated for tuberculosis is required.

  20170820
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  Qualitative endobronchial ultrasound (EBUS) elastography classification of lymph nodes according to the dominant elastographic colour pattern (Figure 1)
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  Diagnostic value of endobronchial ultrasound elastography for the differentiation of benign and malignant intrathoracic lymph nodes Potjanee Korrungruang and Viboon Boonsarngsuk (resp. 12832/ RES-15-983.R2)
  onlinelibrary.wiley.com/doi/10.1111/resp.12979/full (Jul 2017)

  Comment by Dr Mark Lavercombe:
  The authors of this paper outline the use of EBUS elastography for both qualitative and quantitative assessment of mediastinal lymphadenopathy for the presence of malignancy. Their promising findings suggest the need for further study to better define the elastographic features in both benign and malignant conditions, in order to guide the need for TBNA sampling.

  20170608