A selection of publications with educational value in
Lung Cancer
Most recently added articles listed first
- Prediction model on disease recurrence for low risk resected stage I lung adenocarcinoma
(Figure 1 of 10.1111/resp.14508)
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Wang Chun Kwok, Ting Fung Ma, James Chung Man Ho, David Chi Leung Lam, Ko Yung Sit, Mary Sau Man Ip, Timmy Wing Kuk Au, Terence Chi Chun Tam (DOI: 10.1111/resp.14508)
onlinelibrary.wiley.com/doi/10.1111/resp.14508/full (July 2023)Comment by Dr Mark Lavercombe:
In this study from Hong Kong, the authors explore factors predicting disease free survival in patients with surgically resected stage 1 adenocarcinoma. Multivariate analysis was used to build a prediction model that, when applied to a validation cohort, achieved an area under the receiver operating characteristic curve of 0.863. The generalisability of this result is unclear due to the relatively high rate of never smoking and epidermal-growth factor receptor mutation positivity in this cohort.20230530 - Respiratory muscle metabolic activity on PET/CT correlates with obstructive ventilatory defect severity and prognosis in patients undergoing lung cancer surgery
(Figure 1 of 10.1111/resp.14475)
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Kinan El Husseini, Jean-Marc Baste, Anne-Charlotte Bouyeure-Petit, Elodie Lhuillier, Antoine Cuvelier, Pierre Decazes, Pierre Vera, Thomas Similowski, Maxime Patout (DOI: 10.1111/resp.14475)
onlinelibrary.wiley.com/doi/10.1111/resp.14475/full (December 2022)Comment by Dr Mark Lavercombe:
Although reporting of bronchoprovocation testing relies heavily on a change in FEV1 following exposure to the provoking agent, it is plausible that other lung function parameters might provide additional information in the assessment of airway hyperresponsiveness (AHR). In this study, the authors performed lung volume estimation using body plethysmography as part of their protocol for methacholine challenge testing. They demonstrate that specific airway conductance (sGaw) is reduced in a substantial number of patients that did not achieve a reduction of 20% in FEV1, and suggest that incorporation of sGaw leads to a higher sensitivity for AHR.20230428 - PM2.5 exposure and risk of lung adenocarcinoma in women of Taiwan: A case-control study with density sampling Szu-Chun Yang, Fang-Yu Lin, Tzu-I Wu, Chih-Da Wu, Jung-Der Wang (DOI: 10.1111/resp.14316)
(Figure 1 of 10.1111/resp. 14316)
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onlinelibrary.wiley.com/doi/10.1111/resp.14316/full (November 2022)Comment by Dr Mark Lavercombe:
In this large cohort of over 21,000 cases of confirmed lung cancer in women aged 40-80 in Taiwan, a history of ever smoking, living in an urban area, or diagnosis of COPD, prior tuberculosis, or malignant neoplasm were found to be risk factors. An association between time-weighted average exposure to inhaled PM2.5 particles and lung adenocarcinoma is demonstrated, with increased levels of exposure associated with increased malignancy risk. Given the low rate of smoking in adult women in Taiwan (<5%), this data suggests another possible contributor to the development of adenocarcinoma in non-smoking women.20221006 - Risk of cancer incidence in patients with idiopathic pulmonary fibrosis: A nationwide cohort study Hong Yeul Lee, MD; Jinwoo Lee, MD; Chang-Hoon Lee, MD; Kyungdo Han, PhD; Sun Mi Choi, MD (DOI: 10.1111/resp.13911)
Figure 2 of 10.1111/resp. 13911
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onlinelibrary.wiley.com/doi/10.1111/resp.13911/full (Feb 2021)Comment by Dr Mark Lavercombe:
In this large study of over 100,000 patients in the Korea NHIS, the association between a diagnosis of IPF and malignancy is explored. Overall cancer risk is confirmed to be higher (HR-2), largely driven by a significant excess in lung cancer diagnoses (HR-6).20210120 - Inter-observer variation in image interpretation and the prognostic importance of non-expansile lung in malignant pleural effusion Geoffrey A Martin, Andrew C Kidd, Selina Tsim, Paul Halford, Anna Bibby, Nick A Maskell and Kevin G Blyth (DOI: 10.1111/resp.13681)
Figure 3 of 10.1111/resp. 13681
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onlinelibrary.wiley.com/doi/10.1111/resp.13681/full (Mar 2020)Comment by Dr Mark Lavercombe:
Non-expansile lung is considered a contraindication to talc slurry pleurodesis in malignant pleural effusion, however inter-observer agreement for diagnosing non-expansile lung on chest radiography is unknown. This study demonstrates poor correlation between experienced observers. Implications for study design and clinical treatment choices are considered.20200218 - Risk factors for pleural effusion recurrence in patients with Malignancy Horiana B Grosu, Sofia Molina, Roberto Casal, Juhee Song, Liang Li, Javier Diaz-Mendoza, Chakravarthy Reddy, Lonny Yarmus, Dante Schiavo, Michael Simoff, Jared Johnstun, Abu-Awwad Raid, David Feller-Kopman, Hans Lee, Sarina Sahetya, Finbar Foley, Fabien Maldonado, Xin Tian, Laila Noor, Russell Miller, Lakshmi Mudambi, Timothy Saettele, Macarena Vial-Rodriguez, Gerogie A Eapen and David E Ost (DOI: 10.1111/resp.13362)
Figure 3
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onlinelibrary.wiley.com/doi/10.1111/resp.13362/full (Jan 2019)Comment by Dr Mark Lavercombe:
Although malignant pleural effusion can be treated with repeated thoracenteses, identification of patients more likely to suffer recurrence of their effusion might lead to earlier definitive intervention. The authors identify several risk factors for recurrence in their cohort, however further study is required to develop a predictive model with external validity.20181218 - Year in review 2017: Interventional pulmonology, lung cancer, pleural disease and respiratory infections Lonny Yarmus, Phan T Nguyen, Kristina Montemayor, Mark Jennings, Brett Bade, Majid Shafiq, Gerard Silvestri, Daniel Steinfort
onlinelibrary.wiley.com/doi/10.1111/resp.13306 (Apr 2018)20180430 - Usefulness of a routine endoscopic assessment of laryngeal lesions after lung cancer surgery Alex Fourdrain, Florence De Dominicis, Jules Iquille, Sophie Lafitte, Geoni Merlusca, Alejandro Witte Pfister, Patrick Bagan and Pascal Berna (DOI: 10.1111/resp.13139)
Table 3
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onlinelibrary.wiley.com/doi/10.1111/resp.13139/full (Jan 2018)Comment by Dr Mark Lavercombe:
Vocal cord dysfunction is not uncommon in patients after lung cancer resection, and this study demonstrates a significant association with poor post-operative outcomes including pneumonia, need for bronchoscopy and re-intubation. The authors recommend routine laryngeal screening within 24h of surgery, although treatment outcomes were not assessed in this study.20171208 - Natural history and clinical characteristics of multiple pulmonary nodules with ground glass opacity: Yuki Sato, DaichI Fujimoto, Takeshi Morimoto, Keiichiro Uehara, Kazuma Nagata, Ichiro Sakanoue, Hiroshi Hamakawa, Yutaka Takahashi, Yukihiro Imai and Keisuke Tomii (DOI: 10.1111/resp.13089)
Table 3
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onlinelibrary.wiley.com/doi/10.1111/resp.13089/full (Nov 2017)Comment by Dr Mark Lavercombe:
The authors of this paper describe the natural history of single and multiple ground glass nodules (GGN) over a 36 month period. They demonstrate that partly solid and ≥ 10mm size solitary GGN are more likely to progress, while ≥ 10 mm and past history of lung cancer were associated with progression in multiple GGN.20171027 - Diagnostic value of endobronchial ultrasound elastography for the differentiation of benign and malignant intrathoracic lymph nodes Potjanee Korrungruang and Viboon Boonsarngsuk (resp. 12832/ RES-15-983.R2)
Qualitative endobronchial ultrasound (EBUS) elastography classification of lymph nodes according to the dominant elastographic colour pattern (Figure 1)
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onlinelibrary.wiley.com/doi/10.1111/resp.12979/full (Jul 2017)Comment by Dr Mark Lavercombe:
The authors of this paper outline the use of EBUS elastography for both qualitative and quantitative assessment of mediastinal lymphadenopathy for the presence of malignancy. Their promising findings suggest the need for further study to better define the elastographic features in both benign and malignant conditions, in order to guide the need for TBNA sampling.20170608 - Malignant pleural fluid from mesothelioma has potent biological activities. Cheah et al. (resp.12874/ RES-16-044.R1)
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onlinelibrary.wiley.com/doi/10.1111/resp.12874/full (Jan 2017)Comment by Dr Mark Lavercombe:
This original article suggests that malignant pleural effusion in mesothelioma might not be purely a consequence of the malignancy, but could contribute to its pathobiology. This suggests the possibility of future therapeutic targets in this disease.20161220 Interstitial lung disease associated with gemcitabine: A Japanese retrospective cohort study. Hamada et al.
onlinelibrary.wiley.com/doi/10.1111/resp.12665/abstract (Nov 2015)20160819
