No. 119 (June 2019)
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APSR News

This is your world

Dr Kwun Fong's idea of an interactive map has proved to be more popular than first envisaged, with many researchers consulting it as a resource of data for their work.

apsresp.org/education/asia-pacific-health/map.html

We'd like to increase it's value with more information about respiratory health matters in any Asia-Pacific country or region, and would welcome details of any source of reliable data for adding to the map.

Please send ideas, suggestions and data sources to APSRinfo@theapsr.org.

2019 Congress banner

Congress news

Vietnam 2019

Abstracts are now being accepted for the 2019 Congress to be held in Hanoi, Vietnam, 14-17 November 2019, and online registration will be open soon.

The following scientific programme outline is tentative, but gives you a clear idea of the wide range, and depth, of topics covered.

  • Pre-congress Workshops
    • Interpretation of biomarkers in asthma
    • Bronchoscopy and Interventional Techniques - The role of Interventional Pulmonologist in Lung Cancer
    • Chest Radiology for Clinicians
    • EBUS
    • TB and comorbidity
    • Pulmonary function testing: From theory to clinical practice
    • Asthma - Practical skills: Inhaler devices and techniques
    • Pleural Ultrasound
    • Pulmonary function testing: From theory to clinical practice
  • Plenary lecture 1 - Lung cancer - Unleashing the power of the immune system to fight lung cancer
  • Symposia
    • COPD 1 - Diagnosis and management of early COPD
    • Clinical respiratory Medicine 1 - Dyspnea: the most disabling symptom
    • Respiratory Structure and Function 1 - Mechanisms of non-reversible airflow obstruction in asthma
    • Pulmonary Circulation - Management and registry of pulmonary vascular diseases in APSR countries
    • Interstitial lung diseases 1 - Therapeutic strategy of IPF
    • Respiratory neurobiology and sleeps 1 - Ambulatory Monitoring for Respiratory Function Assessment
    • E-cigarette and health
    • Clinical Respiratory medicine 2 - Chronic cough
    • Interstitial lung diseases 2
    • Tuberculosis 1
    • Environmental & occupational health and epidemiology - Treatment for occupational lung disease in Asia
    • Lung Cancer 1
    • Respiratory infections (non-tuberculous) 1
    • Critical care medicine 1 - 52 years of ARDS: what strategies improve outcome?
    • COPD 2 - Personalised management of airway diseases
    • Clinical respiratory Medicine 3 - Treatment beyond medications
    • Critical care medicine 2 - Ventilator-associated pneumonia management in the era of antibiotic resistance
    • Clinical allergy and immunology - Current topics in allergy and airway inflammation
    • Lung Cancer 2
    • Respiratory Infections (nontuberculous) 2
    • Bronchoscopy and interventional techniques - Advances in Interventional Pulmonology
    • Tuberculosis 2
    • Clinical Respiratory medicine 4
    • Paediatric lungs diseases
    • Asthma 1 - New asthma treatment: finding value for money
    • Respiratory neurobiology and sleep 2 - Pathophysiology and Treatments of Dyspnea
    • Paediatric lungs diseases 2
    • Asthma 2 - Asthma: Practical management across the Asia-Pacific
    • Tuberculosis 3
    • Respiratory Structure and Function 2 - Defining COPD beyond FEV1 and Symptoms
    • Asthma 3: Joint with Environmental Assembly
    • Cell and molecular biology 1
    • Clinical allergy and immunology 2

You can download the timetable here (PDF)

Keep checking apsr2019.com regularly for updates.

Travel Award opportunities

A new Young Investigator award has been created for the 2019 APSR Congress in Hanoi, and for several congresses in future years: the APSR / KF-CB Lung Cancer Research Young Investigator Award, which gives US$500 to the selected lung cancer paper accepted for presentation at the Congress.

The award money is jointly funded by Professor Kwun Fong and Professor Chunxue Bai, two of the most widely-respected specialists in respiratory medicine. This prestigious award is to recognise the work of early-career researchers in the area of lung cancer, one the big 5 lung diseases.

Across the range of APSR awards, although the number of female awardees is steadily catching up to the number of male awardees, Professor Fong and Professor Bai would like accelerate the goal of more diversity in scientific excellence. Women APSR members are therefore especially encouraged to compete for this Award.

See apsresp.org/awards/2019/lung-cancer-research.html for details.

JRS Meeting Travel Awardees

As reported in the April 2019 issue of the APSR Bulletin, three APSR Young Investigators were awarded travel assistance to attend the 59th Annual Meeting of the Japanese Respiratory Society on 12-14 April 2019 at the Tokyo International Forum.

Here are their post-conference reports:

Rachel Foong

Ability of the Lung Clearance Index to Monitor the Progression of Early Lung Disease in Children with Cystic Fibrosis

I am grateful to the APSR for providing me with the opportunity to present my research at the Japanese Respiratory Society Annual Meeting in Tokyo. At the meeting, I was also invited to chair the Airway Diseases – Clinical session. It was a great experience to be able to share my findings and also learn about the respiratory research in Japan. There was a lot of diverse research into indoor air pollution, obesity, and new methods for diagnosing and treating asthma presented and I enjoyed discussing the findings with the researchers presenting in these sessions. I was able to learn about new technology treatment strategies. The local presentations were excellent, and everyone did well with addressing questions.

I also enjoyed attending the other sessions and the luncheon seminar. Listening to key invited speakers was made even better when there was a Japanese bento box lunch provided. I also attended many other sessions on sleep, interstitial lung diseases and infections. Researchers from Japan have made important advancements in tuberculosis and idiopathic pulmonary fibrosis and it was certainly a privilege to be able to receive first-hand results in these areas. In particular, I enjoyed learning about new treatments for infections. Attendance at this conference allowed me to advance my knowledge in respiratory medicine. I enjoyed telling my colleagues back home in Australia about my experience and what I had learnt at the JRS conference.

The social programme at the conference was a highlight for me. I attended both the welcome reception and the international reception. I have never had such delicious food at a conference reception, with fresh sushi and soba noodles being prepared at the back of the room. The food at the international reception was exceptional. Great fresh seafood, sushi, noodles and tempura. There was also a Japanese comedian who did a good job keeping us very entertained. It was also a great opportunity to network with Japanese and other international researchers in an informal setting. I was able to discuss my research for potential collaborations and make new friends at the meeting.

Finally, I would like to point out the excellent venue in Tokyo. The conference hall was at a very central location near the Tokyo train station and it was great to have many food options and food trucks on site. I also enjoyed seeing the exhibition hall. Although it was a shame I do not understand Japanese and could not read the poster exhibitions. Tokyo is certainly an amazing city with great food and shopping too. It was safe and clean and everyone was very helpful and friendly. I am very happy to have been able to attend the JRS conference in Tokyo and would love to be able to attend again in future.

Ralph Villalobos

Safety and Efficacy of Beta Blockers in COPD: A review

I am grateful to the APSR for providing me with the opportunity to present my research at the Japanese Respiratory Society Annual Meeting in Tokyo. At the meeting, I was also invited to chair the Airway Diseases – Clinical session. It was a great experience to be able to share my findings and also learn about the respiratory research in Japan. There was a lot of diverse research into indoor air pollution, obesity, and new methods for diagnosing and treating asthma presented and I enjoyed discussing the findings with the researchers presenting in these sessions. I was able to learn about new technology treatment strategies. The local presentations were excellent, and everyone did well with addressing questions.

I also enjoyed attending the other sessions and the luncheon seminar. Listening to key invited speakers was made even better when there was a Japanese bento box lunch provided. I also attended many other sessions on sleep, interstitial lung diseases and infections. Researchers from Japan have made important advancements in tuberculosis and idiopathic pulmonary fibrosis and it was certainly a privilege to be able to receive first-hand results in these areas. In particular, I enjoyed learning about new treatments for infections. Attendance at this conference allowed me to advance my knowledge in respiratory medicine. I enjoyed telling my colleagues back home in Australia about my experience and what I had learnt at the JRS conference.

The social programme at the conference was a highlight for me. I attended both the welcome reception and the international reception. I have never had such delicious food at a conference reception, with fresh sushi and soba noodles being prepared at the back of the room. The food at the international reception was exceptional. Great fresh seafood, sushi, noodles and tempura. There was also a Japanese comedian who did a good job keeping us very entertained. It was also a great opportunity to network with Japanese and other international researchers in an informal setting. I was able to discuss my research for potential collaborations and make new friends at the meeting.

Finally, I would like to point out the excellent venue in Tokyo. The conference hall was at a very central location near the Tokyo train station and it was great to have many food options and food trucks on site. I also enjoyed seeing the exhibition hall. Although it was a shame I do not understand Japanese and could not read the poster exhibitions. Tokyo is certainly an amazing city with great food and shopping too. It was safe and clean and everyone was very helpful and friendly. I am very happy to have been able to attend the JRS conference in Tokyo and would love to be able to attend again in future.

Ching-Yao Yang

The Impact of Pre-Treatment PD-L 1 on Clinical Outcomes of Lung Adenocarcinoma Patients with EGFR mutations Receiving Targeted Therapies

(Report to follow)

APSR & ISRD Joint Session at the ATS 2019

The APSR & ISRD Joint Session was successfully held at the ATS 2019, Dallas last month.

Details of the session can be seen at apsresp.org/publications/bulletin/2019/11841a8a.html#item03 and an 8-second video file of the audience and presenters can be seen at apsresp.org/images/bulletin/2019/06/isrd.mov

Our Members, Our Future

Continuing this series we are delighted to share a tribute to Prof. Mary Sau-Man Ip, prepared by Dr David CL Lam.

This series complements our APSR Members' Honour Roll, on which as a member, you are welcome to add your appreciation of your mentor(s) at any time.


Prof. Ip

A tribute to Prof. Mary Sau-Man Ip

Professor Mary Sau-Man Ip graduated from the University of Hong Kong (HKU) in 1978. She initially worked as medical officer in the University Medical Unit at Queen Mary Hospital (QMH) and subsequently joined her alma mater as academic staff in 1985. She served as Associate Dean in Education at the Medical Faculty for 13 years, and recently as Head of Medicine from 2016 to 2019. She has been Chief of Division of Respiratory and Critical Care Medicine at QMH, HKU since 2008.

Professor Ip pioneered research in sleep-disordered breathing in Hong Kong in the 1990s. At that time, obstructive sleep apnea was not well recognized in the Asian community until she drew attention to the problem. In the late 1990s, she led a ground-breaking study of obstructive sleep apnea syndrome in Hong Kong in which more than 1,500 middle-aged community-based adults were surveyed and clinically assessed. Since then, this hitherto under-appreciated medical condition became progressively known by the professional community and the public in Hong Kong. Her subsequent work on the association of sleep apnea with cardio-metabolic disorders, in particular glucose metabolism, is internationally recognized. Other than sleep disordered breathing, she has avid clinical interests in clinical medicine, and mentors or participates in clinical research projects in a range of respiratory diseases. She has also led the local professional societies in Hong Kong in multi-centre studies to establish updated reference values for lung function in adults and children for territory-wide clinical application, which also subsequently contributed to the formulation of multi-ethnic reference sets.

With such tremendous research contributions to research and professional education, she was awarded the APSR Harasawa Award for Research Excellence in 2010 and the APSR Medal in 2013. She was also President of the APSR from 2010 to 2012, and is currently Chairperson of the APSR Strategic Planning Committee.

With all the above engagement, Prof Ip is always being seen as an all-rounded academic leader who can steer impactful clinical research, innovate professional education and administrative roles in clinical respiratory medicine. She is able to inspire and motivate the next generation of healthcare professionals to engage in the advancement in respiratory medicine.

Prepared by Dr David CL Lam, MD, PhD, FRCP, FCCP, FACP, FAPSR
Clinical Associate Professor, Department of Medicine, HKU

"I first met Prof Ip in 1991 as a medical student in a bedside teaching session with her being the teacher. Since then, my role has changed from being her medical specialty trainee to working in the same division with her for research, medical education and clinical service."

Respiratory Updates

The May issue (Vol 11.5) features Recent progress in the pathogenesis and management of pulmonary vascular diseases:

  • Haemodynamic definitions and updated clinical classification of pulmonary hypertension
  • Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis
  • Genomic comparison with supercentenarians identifies RNF213 as a risk gene for pulmonary arterial hypertension
  • Bmpr2 mutant rats develop pulmonary and cardiac characteristics of pulmonary arterial hypertension
  • Selenoprotein P promotes the development of pulmonary arterial hypertension: A possible novel therapeutic target
  • Pathology and pathobiology of pulmonary hypertension: state of the art and research perspectives
  • Effect of the pulmonary embolism rule-out criteria on subsequent thromboembolic events among low-risk emergency department patients
  • Comparison of an oral factor Xa inhibitor with low molecular weight heparin in patients with cancer with venous thromboembolism: results of a randomized trial (SELECT-D)
  • The ADAMTS13-VWF axis is dysregulated in chronic thromboembolic pulmonary hypertension
  • Subpleural perfusion predicts failure after balloon pulmonary angioplasty for nonoperable chronic thromboembolic pulmonary hypertension.

Inside Respirology

Vol. 24 Issue 6

EDITORIALS
502Obesity and the lungs: Not just a crush
Gregory G King MBChB, PhD, FRACP, Cindy Thamrin PhD
10.1111/resp.13532
504How best to assess cough as an outcome measure
Richard S Irwin MD, Cynthia L French PhD
10.1111/resp.13541
506Azithromycin and ABBA in the chest clinic: 'The winner takes it all...'
Peter G Gibson MBBS, D Med, FRACP, FAPSR, FAAHMS
10.1111/resp.13545
508Treatment of interstitial lung disease: Do the ends justify the means?
Daniel J Kass MD
10.1111/resp.13526
510Predicting which children have asthma: Are we any closer to finding the Holy Grail?
Peter D Sly MBBS, MD, FRACP, DSc
10.1111/resp.13529
INVITED REVIEW SERIES
Non-invasive ventilation
512Respiratory adjuncts to NIV in neuromuscular disease
Nicole Sheers, Mark E Howard, David J Berlowitz
10.1111/resp.13431
521NIV in amyotrophic lateral sclerosis: The 'when' and 'how' of the matter
Capucine Morelot-Panzini, Gaëlle Bruneteau, Jesus Gonzalez-Bermejo
10.1111/resp.13525
INVITED REVIEW
531Endobronchial ultrasound-guided transbronchial needle aspiration in sarcoidosis: Beyond the diagnostic yield
Rocco Trisolini, Robert P Baughman, Paolo Spagnolo, Daniel A Culver
10.1111/resp.13537
ORIGINAL ARTICLES
Asthma and Allergy
543BMI but not central obesity predisposes to airway closure during bronchoconstriction
Ubong Peters, Meenakumari Subramanian, David G Chapman, David A Kaminsky, Charles G Irvin, Robert A Wise, Gwen S Skloot, Jason H T Bates, Anne E Dixon
10.1111/resp.13478

The effect of body mass index (BMI) and waist circumference (WC) on spirometric lung function and airway closure during induced bronchoconstriction was assessed in patients with asthma. WC, but not BMI, was associated with restrictive effects on baseline spirometry. However, during bronchoconstriction, airway closure was associated with increased BMI, rather than WC.

551Development and validation of the COugh Assessment Test (COAT)
Hyeon-Kyoung Koo, Ina Jeong, Joo-Hee Kim, Sung-Kyoung Kim, Jong-Wook Shin, So Young Park, Chin Kook Rhee, Eun Young Choi, Ji-Yong Moon, Yee Hyung Kim, Hyun Lee, Hye Seon Kang, Kyung Hoon Min, Jin Woo Kim, Je Hyeong Kim, Sang Haak Lee, Kwang Ha Yoo, Deog Kyeom Kim, Hyoung Kyu Yoon, Dong-Gyu Kim, Hui Jung Kim, Ki-Suck Jung, Seung Hun Jang, on behalf of the Cough Study Group of the Korean Academy of Tuberculosis and Respiratory Diseases
10.1111/resp.13462

The COugh Assessment Test (COAT) is a simple assessment that has good repeatability, reliability and validity, with clear discriminative properties. The COAT might serve as a useful parameter for the evaluation of chronic cough in clinic and research settings.

Bronchiectasis
558
Idiopathic chronic productive cough and response to open-label macrolide therapy: An observational study
Matthew J Martin, Helen Lee, Carly Clayton, Kate Pointon, Irshad Soomro, Dominick E Shaw, Tim W Harrison
10.1111/resp.13483

A group of patients with chronic productive cough of unknown cause not adequately described by existing disease labels is described in terms of their physiological, radiological and pathological features. The majority of these patients demonstrated neutrophilic or paucigranulocytic airway inflammation and their symptoms responded well to azithromycin.

Interstitial Lung Disease
566
Therapeutic burden in interstitial lung disease: Lessons to learn
Yet H Khor, Ian Glaspole, Nicole S L Goh
10.1111/resp.13480

This is the first study providing insights into the significance of therapeutic complexity and polypharmacy in patients with interstitial lung disease (ILD). Patients receiving systemic corticosteroids are at high risk of drug–disease interactions. Additional studies are needed to evaluate the impacts of therapeutic burden on clinical outcomes in patients with ILD.

Paediatric Lung Disease
572Urine metabolic profiles in paediatric asthma
Jia-Lei Tao, Yan-Zhen Chen, Qi-Gang Dai, Man Tian, Shou-Chuan Wang, Jin-Jun Shan, Jian-Jian Ji, Li-Li Lin, Wei-Wei Li, Bin Yuan
10.1111/resp.13479

We investigated metabolic profiles of paediatric asthma patients to identify asthma-specific biomarkers in urine. A combination of eight metabolites showed excellent discrimination across groups. Enrichment analysis identified complex biological processes associated with immunity, inflammation, oxidative stress and DNA damage. These approaches enabled discrimination between asthma stages and elucidate its mechanisms.

Sleep and Ventilation
582Pharyngeal distensibility during expiration is an independent predictor of the severity of obstructive sleep apnoea
Ning-Hung Chen, Shih-Wei Lin, Li-Pang Chuang, Peter A Cistulli, Meng-Jer Hsieh, Kuo-Chin Kao, Yu-Fang Liao, Li-Fu Li, Cheng-Ta Yang
10.1111/resp.13474

We have devised an image-based method that can rapidly assess obstructive sleep apnoea (OSA) severity in awake patients. We have shown that, in awake patients, airway distensibility/collapsibility during expiration, but not inspiration, is related to the severity of OSA. Airway distensibility is an independent risk factor for OSA, but not related to anatomical changes in the tongue and soft palate.

POSITION STATEMENT
590Emerging respiratory infections threatening public health in the Asia-Pacific region: A position paper of the Asian Pacific Society of Respirology
Sunghoon Park, Ji Young Park, Yuanlin Song, Soon Hin How, Ki-Suck Jung, on behalf of the Respiratory Infections Assembly of the APSR
10.1111/resp.13558
CONTEMPORARY CONCISE REVIEW
598Contemporary Concise Review 2018: Respiratory infections and tuberculosis
David S Hui, Chi-Chiu Leung
10.1111/resp.13542
LETTER FROM ASIA-PACIFIC AND BEYOND
605Letter from Italy
Alberto Papi MD
10.1111/resp.13554
CORRESPONDENCE
607Airway distensibility: Bringing physiology to the bedside
Andrew Wellman MD, PhD
10.1111/resp.13551
607Airway distensibility: Bringing physiology to the bedside – Reply
Ning-Hung Chen MD, Shih-Wei Lin MD, Li-Pang Chuang MD
10.1111/resp.13548

Inside Respirology Case Reports

The following two cases have been added to the July 2019 Respirology Case Reports, Volume 07 Issue 5

Case Reports

Bronchiectasis in the setting of aplasia of the epiglottis
Puwakdandawe Weerasinghe, Rahul Thomas, Brent Masters, Nitin Kapur
DOI: 10.1002/rcr2.430

Aplasia of the epiglottis is a rare airway abnormality requiring airway and feeding interventions. We report a case of bronchiectasis in the setting of congenital aplasia of the epiglottis, secondary to early-life aspiration events in a 2-year-old male with recurrent lower respiratory track infections.

Acute shortness of breath due to reoccurrence of an intrapericardial bronchogenic cyst
Damian Gimpel, Joseph Conway, Felicity Meikle, Zaw Lin, David John McCormack, Adam El-Gamel
DOI: 10.1002/rcr2.431

A 71-year-old woman presented with dysphagia and acute shortness of breath. Surgical history included a prior thoracotomy overseas for a bronchogenic mesothelial cyst 19 years before. Computed tomography demonstrated a mass within the posterior mediastinum. A median sternotomy was performed, and after removal of the cyst, repair of the left atrium and pulmonary vessels was undertaken due to the invading nature of the cyst. Irrespective of the method of approach in redo surgery, complete resection must be performed in order to minimize the chance of recurrence, relieve symptoms, eliminate risk of infection, and prevent malignant degeneration.

The following cases have been selected to open the new August 2019 Respirology Case Reports, Volume 07 Issue 6

Case Reports

Pulmonary endometriosis: a rare cause of hydropneumothorax
Husam Alzayer
DOI: 10.1002/rcr2.432

Pulmonary involvement in endometriosis is well described in the literature but asymptomatic significant hydropneumothorax is considered an unusual presentation. We present a rare case of catamenial hydropneumothorax confirmed through a pleural biopsy.

Multiple primary lung adenocarcinomas pre-operatively diagnosed by discordant epidermal growth factor receptor mutations
Yuki Katayama, Sayaka Kawai, Aya Miyagawa-Hayashino, Yoshizumi Takemura
DOI: 10.1002/rcr2.434

We describe a case of simultaneous multiple bilateral lung adenocarcinomas diagnosed by discordant epidermal growth factor receptor mutations in transbronchial lung biopsy specimens that led to a successful radical surgery.

Spontaneous cerebrospinal fluid rhinorrhoea and aspiration pneumonitis following initiation of continuous positive airway pressure treatment for obstructive sleep apnoea
Sanjiwika Lalanjani Wasgewatta, Nathan Manning, Michael Redmond, Diane Howard, Subash Shanthakumar Heraganahally
DOI: 10.1002/rcr2.435

We describe a 53-year-old woman with severe obstructive sleep apnoea (OSA) and intracranial hypertension who developed spontaneous cerebrospinal fluid (CSF) rhinorrhoea and CSF aspiration pneumonitis as a complication following initiation of CPAP therapy for OSA management.

Clinical Images

Multiple fungus balls in a patient with chronic pulmonary aspergillosis
Keitaro Nakamoto, Yuka Sasaki, Takashi Uchiyama, Ken Ohta
DOI: 10.1002/rcr2.433

We present an atypical but very educational case of a 76 year-old man with interstitial lung disease diagnosed with chronic pulmonary aspergillosis who presented with multiple fungus balls in the right lower lobe.

Regional society news

The spotlight this month is on

JAPAN

Each month we share details of activities of a particular country, region or society.

If you would like the spotlight to be on your country, region or society next month, contact the Bulletin Coordinator or APSR Secretariat.

Japanese Respiratory Society (JRS)
Activity report for 2018

JRS Annual Meeting

The JRS held its 58th Annual Meeting on 27-29 April 2018 in Osaka, under the presidency of Professor Kazuto Hirata. The theme was "Respirology; Its track to date and its clear future concept". There were about 7,600 attendees and the JRS received about 100 English abstract submissions.

The 59th Annual Meeting of the JRS will be held in Tokyo, 12-14 April 2019 under the presidency of Professor Koichiro Tatsumi. The theme is "Efforts toward Epoch-making Innovation in Respiratory Medicine – The Formation of the Human Chain Network"

We are expecting many participants from overseas. The programme will be updated as new information becomes available on website: www.jrs.or.jp/jrs59/en

JRS Official Journals

The JRS official Japanese-language journal is called Annals of the Japanese Respiratory Society and we also have official English-language journal called Respiratory Investigation. These are published bimonthly.

Respiratory Investigation is peer-reviewed journal and open access for Topic Series, Guidelines and Consensus Statements.

It reports significant original manuscripts on clinical investigations of respiratory diseases and medicines, along with articles concerning basic lung cellular and molecular biology and respiratory mechanics. In particular, to better understand the regional characteristics of respiratory disorders, investigations based on current knowledge of genomic specificity of East Asian ethnics are welcome. The journal presents current accomplishments in this field as Original Articles, Case Reports, Reviews and Guidelines, Editorials, and Letters to the Editor.

The JRS applied for an impact factor in March 2016. We look forward to receiving your manuscript. The journal accepts contributions from members and non-members of the Society.

Other notable society events and news:

Indonesia

Asthma: Admirable Action!

It's impossible not to admire the energy and great organising ability of the Indonesian Society of Respirology (ISR) exercised for the 2019 World Asthma Day.

The ISR's Prof. Faisal Yunus reports:

In commemorating the World Asthma Day, the Indonesian Society of Respirology carried out several activities.

The first activity was carried out on 4 May 2019 in the city of Malang in East Java in the form of a symposium on the management of asthma which was attended by 210 primary health care doctors and pulmonary specialists. There were three topics discussed at the event, namely the management of stable asthma, the management of acute exacerbation asthma, and the role of anti-inflammation in the management of asthma.

On 5 May 2019 a webinar was held in Jakarta. This event was participated by pulmonary specialists from 15 cities in Indonesia. At the event, the latest asthma guidelines (GINA 2019) was disseminated to the participants.

On 7 May 2019 a press conference was held in Jakarta attended by 16 electronic media, newspaper and television journalists. The reporters were asked to inform the public about asthma, how much the problem of asthma, the purpose of managing the disease, and how to make asthma controlled.

On the same day, another webinar was held which was also participated by pulmonary specialists from 10 cities in Indonesia. This time the webinar programme discussed the management of asthma in difficult asthma cases.

(Click any photo to enlarge)

Republic of Korea

2019 International Conference of the KATRD

The 2019 International Conference of the Korean Academy of Tuberculosis and Respiratory Diseases (KATRD) will be held at Lotte Hotel World from 7 to 8 November 2019

Invited speakers include

  • Dr Arata Azuma (Japan)
  • Dr Shih-Lung Chen (Taiwan)
  • Dr Luca Richeldi (Italy)
  • Dr David Singh (UK)
  • Dr Jeffrey Hafkin (Japan)
  • Dr Parameswaran Nair (Canada)

For travel grant opportunities, abstract submission, registration and further details, see www.katrdic.org


(Click to enlarge)

Sri Lanka

Respire 11

The Sri Lankan government is enhancing security measures in response to the heinous terrorist attacks on Easter Sunday which led to the violent deaths of over 250 people. Consequently, the Sri Lanka College of Pulmonologists (SLCP) has taken the prudent decision to postpone the Respire 11 academic meeting which was originally scheduled for 3–5 July. The new dates are 29–31 October 2019.

The venue is the same Galadari Hotel in Colombo and the programme remains unchanged.

SLCP president Dr Saman Kapilawansa says:

The Council has not made this decision lightly and understands the inconvenience caused to you by these alterations. Safety is however of utmost importance in this situation and we are certain you are of the same understanding.

We hope you will be able to join us in October for Respire 11 on the revised dates.

Your continued support is of immense value to us during these difficult times. Please do not hesitate to contact us for further information.

Thank you
Dr Saman Kapilawansa
President
Sri Lanka College of Pulmonologists
Consultant Respiratory Physician

Respire 11 Abstract submission: docs.google.com/forms/d/1bAKXrL1Ms7lqQz7IOSzxncIj1C1A0lJEud11ehsPHN4/viewform?edit_requested=true

Extra-regional societies

Panama

The 12th Congress of the Asociación Latinoamericana del Tórax (ALAT) will take place at the ATLAPA Convention Center in Panama City 3–6 July 2019.

By the kind invitation of Congress Scientific Committee, Dr Kwun Fong (APSR President) and Dr David C L Lam (Immediate Past Chair of the APSR Education Committee) will be the APSR's representative speakers at the Congress.

The symposium APSR–ALAT–WHO essential medicine for respiratory illnesses: unique window of opportunity to address global equity, will be held on 08:00 – 10:00 on 6 July in La Huaca Room of the conference centre:

  • "Access of essential medicines in smoking cessation"
    Dr David C L Lam
  • "Access of essential drugs in COPD: LAMA"
    Dr Rogelio Perez Padilla
  • "Access of essential medicines in lung cancer"
    Dr Kwun Fong
  • "Access of essential medicines in Asthma: LABA / ICS"
    Dr Federico Daniel Colodenco
  • Q&A

The APSR is looking forward to collaborating further with the ALAT in the future.

Ibero-Latino-American region

Declaration of the Ibero-Latino-American respiratory scientific societies on Electronic Nicotine Delivery Systems

The main scientific societies of pneumology and thoracic surgery of the Ibero-Latino-American region, after meetings held in different national congresses in which the published data on the nicotine release electronic devices (ENDS) were analyzed, would like to make the following manifest: (Statement)

  1. The most effective and also safest treatment to help smokers give up smoking is the combination of psychological counseling and pharmacological treatment. There are three pharmacological treatments with demonstrated effectiveness: nicotine replacement therapy (chewing gum, patches, tablets, candy, inhalers and spray), bupropion and varenicline. All of them used at standard doses and time are able to double and even triple the chances of quitting. (1,2,3)
  2. The scientific analysis of most of the studies carried out to date shows that ENDS have not shown effectiveness or shown very limited effectiveness in smoking cessation (4-5)
  3. The ENDS have not demonstrated safety. There are multiple independent studies that indicate adverse effects in the short term. In addition, the occurrence of adverse effects in the medium-long term cannot be ruled out, today unknown due to the short observation period. (6-8) On the other hand, they are being promoted by aggressive promotional campaigns that use brand identity and focus on young people and adolescents, campaigns similar to those used by tobacco companies in the 20th century, with the aim of recruiting users by making them addicted to nicotine.
  4. Based on the above, we affirm that health professionals should never recommend the use of this type of devices.
  5. In smokers who face severe difficulties to quit smoking or in those in whom the use of standard dose and time treatments have failed, we recommend the use of combined intense psychological counseling plus the prescription of pharmacological treatment (substitution therapy with nicotine, bupropion and varenicline) at high doses and for a long time. (9)
  6. The analysis of various studies shows that electronic devices for the release of nicotine allow the inhalation of other substances (flavourings, cocaine, synthetic drugs and cannabis derivatives, among others) which, in addition to the addictive power, add new potential toxicities that can adversely affect the respiratory system. (6-8)
  7. Breathing clean air is mandatory for respiratory health. Direct or second-hand inhalation of smoke and / or aerosols generated by ENDS or other devices represents a threat to respiratory health. All parts and structures of the respiratory system are perfectly arranged and made to meet one of the main needs that human beings have: the breathing of clean and oxygenated air, without it life would not be possible.
  8. The societies of professionals committed to healthy breathing, alert the general public to avoid the use of any type of device that facilitates the inhalation of foreign substances, the safety of which has not been proven scientifically.
References
  1. Fiore MC, Jaén CR, Baker TB, Bailey WC, Benowitz NL, Curry SJ, et al. Treating Tobacco Use and Dependence: 2008 Update. Clinical Practice Guideline. Rockville, MD: U.S. Department of Health and Human Services. Public Health Service; 2008. Traducción al español: Jiménez Ruiz CA, Jaén CR (coordinadores de la traducción). Guía de tratamiento del tabaquismo. Sociedad Española de Neumología y Cirugía Torácica (SEPAR); 2010.
  2. Anthenelli RM, Benowitz NL, West R, St Aubin L, McRae T, Lawrence D, et al. Neuropsychiatric safety and efficacy of varenicline, bupropion, and nicotine patch in smokers with and without psychiatric disorders (EAGLES): a double-blind, randomized, placebo-controlled clinical trial. Lancet. 2016;387(10037):2507-20.
  3. Hartmann-Boyce J, Chepkin SC, Ye W, Bullen C, Lancaster T. Nicotine replacement therapy versus control for smoking cessation. Cochrane Database Syst Rev. 2018; 5:CD000146.
  4. Hartmann-Boyce J, McRobbie H, Bullen C, Begh R, Stead LF, Hajek P. Electronic cigarettes for smoking cessation. Cochrane Database Syst Rev. 2016 Sep 14;9:CD010216
  5. Hajek P, Phillips-Waller A, Przulj D, et al. A randomized trial of e-cigarettes versus nicotine-replacement therapy. N Engl J Med 2019; 380: 629-37.
  6. Bals R, Boyd J, Esposito S, Foronjy R, Hiemstra PS, Jiménez-Ruiz CA et al. Electronic cigarettes: a task force report from the European Respiratory Society. Eur Respir J. 2019; 31;53(2).
  7. Zabert G , Gaga M, Jiménez Ruiz C, Buljuvacich D, García G, Vázquez J, Ravara S y Bello S. Cigarrillo electrónico y demás ENDS: posición de sociedades científicas respiratorias. Revista Americana de Medicina Respiratoria RAMR. 2019; vol 19 N 2.
  8. Signes Costa J, de Granda Orive I, Ramos Pinedo A, Camarasa Escrig A, de Higes Martinez E, Rabade C, Cabrera Cesar E, Jimenez Ruiz CA. Declaración oficial de la Sociedad Española de Neumología y Cirugía Torácica SEPAR sobre cigarrillos electrónicos e IQOS. Arch Bronconeumol. 2019. En prensa.
  9. Jiménez-Ruiz CA, Andreas S, Lewis KE, Tonnesen P, van Schayck CP, Hajek P, et al. Statement on smoking cessation in COPD and other Pulmonary Disorders and in smokers with comorbidities who find it difficult to quit. Eur Respir J. 2015;46(1):61-79.

Health news

Air pollution and NCDs

Following our introduction in the March 2019 issue of the APSR Bulletin on air pollution and NCDs, the related FIRS press release was picked up by the British daily newspaper The Guardian, the world's fifth most popular online newspaper (ref: MediaWeek, 2011). The white text on a black background may cause eye strain for some readers, but it's nice to acknowledge that FIRS press releases sent to such media companies are actioned.

See www.theguardian.com/environment/ng-interactive/2019/may/17/air-pollution-may-be-damaging-every-organ-and-cell-in-the-body-finds-global-review

Education

Emerging respiratory infections threatening public health in the Asia-Pacific region: A position paper of the Asian Pacific Society of Respirology

This position statement has been prepared by members of the Respiratory Infections Assembly and is now published in the latest issue of Respirology:
"Emerging respiratory infections threatening public health in the Asia-Pacific region: A position paper of the Asian Pacific Society of Respirology"; Sunghoon Park, Ji Young Park, Yuanlin Song, Soon Hin How, Ki-Suck Jung. First published 15 April 2019 10.1111/resp.13558

New educational articles

The following article has recently been selected from Respirology for its specific educational value. Previous articles on further topics can be seen at apsresp.org/education/articles/index.html


(Click image to enlarge)

Of special interest to those working in:
* Clinical Respiratory Medicine
* Critical Care Medicine

Development and validation of the COugh Assessment Test (COAT) Hyeon-Kyoung Koo, Ina Jeong, Joo-Hee Kim, Sung-Kyoung Kim, Jong-Wook Shin, So Young Park, Chin Kook Rhee, Eun Young Choi, Ji-Yong Moon, Yee Hyung Kim, Hyun Lee, Hye Seon Kang, Kyung Hoon Min, Jin Woo Kim, Je Hyeong Kim, Sang Haak Lee, Kwang Ha Yoo, Deog Kyeom Kim, Hyoung Kyu Yoon, Dong-Gyu Kim, Hui Jung Kim, Ki-Suck Jung, Seung Hun Jang on behalf of the Cough Study Group of the Korean Academy of Tuberculosis and Respiratory Diseases
onlinelibrary.wiley.com/doi/10.1111/resp.13462 (January 2019)

Comment by Dr Mark Lavercombe:
A simple tool to measure chronic cough and its impact on daily life can be useful for ongoing outpatient or clinic assessment of patients with this condition. In this paper, the authors develop and validate a 5-point questionnaire that correlates well with other tools and demonstrates reliability and validity in a Republic of Korean population.

Session videos from 2018 Congress

Closing down at the end of June, 2019

Until the end of this month only, we are able to share videos of some of the most popular sessions at the APSR Congress in Taipei, 30 November – 2 December 2018.

The videos are streamed, which means you can see them directly – you do not need to download them.

Plenary Lecture 1Cell and molecular biology – Presidential lecture
Symposium 1COPD 1
Symposium 2Clinical respiratory medicine – Presidents' symposium 1
Symposium 3Respiratory structure and function – Emerging technology for pulmonary structure and function
Symposium 5Interstitial lung disease 1 – Pathology of interstitial lung diseases
Symposium 6Respiratory neurobiology and sleep 1 – The impact of home ventilator over the world
Symposium 7E-cigarette and health
Symposium 9Interstitial lung disease 2 – Clinical management of interstitial lung diseases
Symposium 10Tuberculosis 1 – Addressing MDR-TB in the era of end TB strategy
Symposium 11Environmental & occupational health and epidemiology – Particulate air pollution and cardiopulmonary health
Symposium 13Lung cancer 1 – Treatment for oligometastases
Symposium 14Respiratory infections (non-tuberculous) 1 - Invasive pulmonary fungal infection
Symposium 15Critical care medicine 1 – Update in critical care
Plenary Lecture 2Asthma – Memorial lecture 1: Ann Janet Woolcock Research Award
Symposium 17COPD 2
Symposium 18Clinical respiratory medicine – Presidents' symposium 2
Symposium 19Critical care medicine 2 - Management of acute respiratory failure
Symposium 21Lung cancer 2 – Immunotherapy for lung cancer
Symposium 22Respiratory Infections (non-tuberculous) 2 - Pulmonary diseases caused by non-tuberculous mycobacteria (NTM)
Symposium 23Bronchosopy and interventional techniques – Bronchoscopic treatment of benign lung disease
Symposium 24Lung cancer 3 – Update on targeted therapy
Symposium 25Clinical respiratory medicine 1 – Current state of treatment for pleural disease
Symposium 26Paediatric lung disease 1 – Is bronchopulmonary dysplasia preventable?
Symposium 27Clinical respiratory medicine 2 – Update of lung transplantation
Symposium 28Respiratory neurobiology and sleep 2 – The phenotype of obstructive sleep apnea syndrome
Symposium 29Paediatric lung disease 2 – Pediatric asthma
Plenary Lecture 3Respiratory neurobiology and sleep - Memorial lecture 2: Michiyoshi Harasawa Research Award
Symposium 30Asthma 1 – Phenotypes of severe asthma and evolving treatment
Symposium 31Tuberculosis 2 – Management of latent TB infection (LTBI): An update
Symposium 32Clinical respiratory medicine 3 – Recent advance in thoracic imaging biomarker and functional imaging of the chest
Symposium 33Asthma 2 – Novel pathogenesis of severe asthma
Symposium 34Cell and molecular biology – Molecule- and Cell-based Therapeutics in Advanced Lung Diseases
Symposium 35Clinical allergy and immunology – Allergic pathogenesis of non-allergic airway diseases
PR VideoHanoi Promotion Video

As an APSR member you can see these videos at no charge. Further description of each video and the current access password is shown at apsresp.org/congress/apsr2018/streaming.php.

APSR Membership

Donations received

have kindly sent their donations towards the Society's goals, as outlined at apsresp.org/members/donors.php.

The APSR is profoundly grateful for their generosity.

New Fellows of the APSR

Congratulations to the following members who have recently become APSR Fellows.

  • Dr Somnath Bhattacharya FAPSR (India)
  • Dr Catur Elvi Purnamawati FAPSR (Indonesia)
  • Dr Sastia Rakhma FAPSR (Indonesia)
  • Dr Dian Retnowati FAPSR (Indonesia)
  • Dr Azisman Saad FAPSR (Indonesia)
  • Dr Ungky Agus Setyawan FAPSR (Indonesia)
  • Dr Fauzijah Sri Rahmawati FAPSR (Indonesia)

We are also delighted to announce that Dr Noriaki Kurimoto (Japan) has become an honorary member of the APSR.

Assembly news

A new Assembly Newsletter has been uploaded to the Asthma Assembly webpage, announcing new assembly award opportunities.

New assembly members

A warm welcome to the following members who have recently joined APSR assemblies. They will undoubtedly enjoy working with and networking with their assembly colleagues.

Assemblies
Somnath Bhattacharya FAPSR
(India)
Clinical Respiratory Medicine
Lung Cancer
Interstitial Lung Disease
Jamie Chua
(Philippines)
Clinical Respiratory Medicine
COPD
Tuberculosis
Aniket Inamdar
(India)
Clinical Respiratory Medicine
Tuberculosis
Asthma
Sunghoon Park
(Republic of Korea)
Critical Care Medicine
Respiratory Infections (non-tuberculous)
Clinical Respiratory Medicine
Catur Elvi Purnamawati FAPSR
(Indonesia)
Clinical Respiratory Medicine
Asthma
Tuberculosis
Sastia Rakhma FAPSR
(Indonesia)
Respiratory Infections (non-tuberculous)
Tuberculosis
COPD
Dian Retnowati FAPSR
(Indonesia)
Tuberculosis
COPD
Clinical Respiratory Medicine
Ungky Agus Setyawan FAPSR
(Indonesia)
Lung Cancer
Critical Care Medicine
Tuberculosis
Talant Sooronbaev
(Kyrgyzstan)
Critical Care Medicine
Fauzijah Sri Rahmawati FAPSR
(Indonesia)
Tuberculosis
Respiratory Infections (non-tuberculous)
Asthma
Chi Fong Wong
(Hong Kong)
Clinical Respiratory Medicine
Tuberculosis

Future Pulmonology Events

Here are the main respiratory events in Asia-Pacific region for the next few months. You can see our full listing on the APSR Calendar.

  • MTS Annual Congress 2019
    18-21 July 2019, Kuala Lumpur, Malaysia
    (Details)
  • Annual Scientific Congress of Ho Chi Minh City Society of Asthma, Allergy & Clinical Immunology
    21 July 2019, Ho Chi Minh City, Vietnam
    (Details)
  • World Lung Cancer Day
    1 August 2019, Worldwide
    (Details)
  • 16th Annual Meeting: Work Conference of the Indonesian Society of Respirology (ISR)
    11-14 September 2019, Surakarta, Central Java, Indonesia
    (Details)
  • World Lung Day
    25 September 2019, Worldwide
    (Details)
  • WASOG/JSSOG 2019 (Joint Conference of International Conference on Sarcoidosis and Interstitial Lung Diseases 2019, and 39th Annual Meeting of Japan Society of Sarcoidosis and other Granulomatous Disorders)
    9–11 October 2019, Pacifico Yokohama, Japan
    (Details)
  • Respire 11 annual academic sessions of the Sri Lanka College of Pulmonologists
    29–31 October 2019, Colombo, Sri Lanka
    www.copsl.lk
  • Autumn Respiratory Seminar 2019 of the Hong Kong Thoracic Society and CHEST Delegation Hong Kong and Macau Limited
    November (to be confirmed), Hong Kong
    (www.hktsmeetings.com (under construction)
  • PULMOCON 2019 (6th International Conference on Lung Health of BLF)
    4–6 November, Dhaka, Bangladesh
    (Details)
  • 128th Conference of the Korean Academy of Tuberculosis and Respiratory Diseases (KATRD)
    7–8 November 2019, Seoul, Republic of Korea
    (Details)
  • 24th Congress of the APSR
    14–17 November 2019, Hanoi, Vietnam
    (Details)
  • Asthma & COPD Outpatient Care Unit (ACOCU) Network Day
    17 November 2019, Ho Chi Minh City, Vietnam
    (Details)
  • World Lung Day
    12 November 2019, Worldwide
    (Details)
  • World COPD Day
    20 November 2019, Worldwide
    (Details)
  • World AIDS Day
    1 December 2019, Worldwide
    Details)

For more pulmonology events, see apsresp.org/calendar.html
(These events are for information only and APSR endorsement should not be assumed.)

Contact

If you have news or announcements that may be of interest to other APSR members, please send details to Bulletin Coordinator Dr Arata Azuma (a-azuma@nms.ac.jp) or APSR Bulletin (bulletin@apsresp.org).


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