Respirology Case Reorts

Satoshi Nakahara, Yumiko Ishii, Reika Egashira, Kazuya Tsubouchi, Mikihiro Kohno, Tomoyoshi Takenaka, Kentaro Tanaka, Isamu Okamoto
DOI: 10.1002/rcr2.1334

We report the first case of drug-induced interstitial lung disease attributed to lemborexant.

Pitirat Panpruang, Dararat Eksombatchai, Viboon Boonsarngsuk
DOI: 10.1002/rcr2.1348

We present two patients who developed tracheobronchomalacia (TBM) following allogeneic haematopoietic stem cell transplantation (HSCT) and were initially treated for post-transplant bronchiolitis obliterans syndrome (BOS) but did not experience symptom improvement. However, after treatment with continuous positive airway pressure, their symptom subsided.

Takahito Nakaya, Yoshimitsu Hirai, Hiroaki Akamatsu, Fumiyoshi Kojima, Hideto Iguchi, Aya Fusamoto, Yumi Yata, Takahiro Nagai, Daiki Kitahara, Toshiaki Takakura, Yoshiharu Nishimura, Nobuyuki Yamamoto
DOI: 10.1002/rcr2.1358

Neoadjuvant nivolumab plus chemotherapy followed by resection for superior sulcus tumour with high PD-L1.

Claude S Farah, Leigh M Seccombe, Greg G King, David G Chapman, Charles G Irvin
DOI: 10.1002/rcr2.1360

A 64-year-old gentleman with obesity and moderate COPD attended for further evaluation of ongoing dyspnoea despite treatment with dual long acting bronchodilators. A cardiopulmonary exercise test (CPET) was performed, which demonstrated reduced peak work and oxygen consumption with evidence of dynamic hyperinflation, abnormal gas exchange and ventilatory limitation despite cardiac reserve. The CPET clarified the physiological process underpinning the patient's dyspnoea and limiting the patient's activities. This, in turn, helped the clinician tailor the patient's management plan.

Khai Tam, Michael Wallace, Siobhain Mulrennan
DOI: 10.1002/rcr2.1363

An 81 year old male with Child-Pugh A cirrhosis and metastatic hepatocellular carcinoma (HCC) treated with 3-weekly atezolizumab and bevacizumab developed a pulmonary sarcoid-like reaction (SLR) after 5 months. Atezolizumab was identified as the likely culprit. He was treated with prednisolone, resulting in improvement, and was successfully rechallenged with both atezolizumab and bevacizumab.

Hiroyuki Miura, Jun Miura, Shinichi Goto, Tomoko Yamamoto
DOI: 10.1002/rcr2.1364

This article is a case of pulmonary primary MALT lymphoma with characteristic bronchoscopy findings. Immunochemical staining of IRTA-1 was especially useful for diagnosis.

Susumu Noguchi, Atsushi Okamoto, Jun Nohara, Manabu Ishitoko, Toshiki Watanabe, Takaya Nakamura
DOI: 10.1002/rcr2.1366

We experienced a case of long-term response to ipilimumab+nivolumab+carboplatin+paclitaxel for spindle cell carcinoma. The patient also showed efficacy in brain metastasis.

Rodrigo Funes-Ferrada, Alanna Barrios-Ruiz, Alejandra Yu Lee-Mateus, Margaret M Johnson, Sebastian Fernandez-Bussy, David Abia-Trujillo
DOI: 10.1002/rcr2.1367

We report a case of severe ECAC presenting with chronic cough that was successfully managed with long-term pneumatic stenting with CPAP and a literature review on this therapeutic approach.

Rino Arai, Mizuka Tanifuji, Asuka Nagai, Akinori Ebihara, Tokuzen Iwamoto, Shinnosuke Onaka, Mayumi Aoyama, Makoto Otaki, Hidenobu Shigemitsu, Ichiro Kuwahira
DOI: 10.1002/rcr2.1369

We herein report a rare case of endobronchial mucosa-associated lymphoid tissue (MALT) lymphoma (EML) that was diagnosed through a chest computed tomography (CT) during an annual health checkup which was successfully treated with radiotherapy. To the best of our knowledge, only 48 cases of EML have been reported in the literature and are summarized here.

Yuki Takigawa, Ken Sato, Tomoyoshi Inoue, Akiko Sato, Yui Furutaguchi, Mayu Goda, Keisuke Shiraha, Miho Fujiwara, Suzuka Matsuoka, Sho Mitsumune, Hiromi Watanabe, Kenichiro Kudo, Keiichi Fujiwara, Takuo Shibayama
DOI: 10.1002/rcr2.1383

A woman in her mid-50s was admitted to our hospital with airway stenosis secondary to mediastinal lymph node enlargement and the AERO stent was placed under rigid bronchoscopy. Metastatic lesions were found to have an EGFR mutation. The tumour achieved a partial response to osimertinib, and the patient underwent stent removal.

Tetsuo Tani, Tomohiro Takehara, Kota Ishioka, Ayumi Yoshifuji, Kotaro Aoki, Saeko Takahashi
DOI: 10.1002/rcr2.1384

We report a rare case of pneumonia and bacteremia caused by Bacillus subtilis subsp. natto in an immunocompetent patient. B. subtilis subsp. natto is a gram-positive spore-forming bacteria and a subspecies of B. subtilis. Natto is a Japanese traditional food made by fermenting soybeans with B. subtilis subsp. natto which can produce nattokinase.

Teresa Calari, Simone Petrarulo, Alessandra Dubini, Sara Piciucchi, Claudia Ravaglia, Venerino Poletti
DOI: 10.1002/rcr2.1385

This clinical case demonstrates that in specific contexts, EBUS-cryobiopsy represents an excellent diagnostic tool. A young man was brought to our attention after already undergoing a non-diagnostic trans thoracic needle aspiration (TTNA) procedure for lung consolidations. In our department, he underwent an initial EBUS-TBNA procedure with inconclusive rapid on-site evaluation (ROSE), leading to the decision to perform an EBUS-guided cryobiopsy, which yielded a diagnosis of granulomatosis with polyangiitis without complications.

Hwan Jin Lee, Jae Seok Jeong, Yong Chul Lee
DOI: 10.1002/rcr2.1365

We report a rare case that enhancing pleural thickening, confirmed as CFTP through pathological examination, despite the absence of visible calcification on radiological imaging.

Hirokazu Tokuyasu, Yoshitoshi Sato, Yuriko Sueda, Hiromitsu Sakai, Chika Esumi, Akira Yamasaki
DOI: 10.1002/rcr2.1352

We report a case of nivolumab-induced organizing pneumonia with reversed halo sign. Interestingly, the reversed halo sign expanded concentrically.

Yung-Chia Huang, Chen-En Hsieh, Yei-San Hsie, Shih-Wei Lee
DOI: 10.1002/rcr2.1368

We present a case where surgical intervention was successful for the treatment of pulmonary arteriovenous malformation

Matthew T Donnan, Eli Dabscheck, Belinda R Miller, Samantha J Ellis, Matthew T Naughton
DOI: 10.1002/rcr2.1382

Swyer-James-MacLeod Syndrome is a rare obliterative lung disease typically caused by childhood infection resulting in arrested pulmonary development. Imaging findings include unilateral hyperlucency on chest x-ray, and hyperlucency, hypovascularity and expiratory gas trapping on computed tomography. Recognition of abnormal imaging can lead to earlier diagnosis and institution of appropriate management.

Yoshiaki Kinoshita, Kengo Takata, Hisako Kushima, Hiroshi Ishii
DOI: 10.1002/rcr2.1386

We present the first report of a case of a radiological target sign that was potentially associated with drug-induced lung injury. A target sign of the lung consists of a ring-like opacity and a central nodular opacity and has been limited so far to reports associated with SARS-CoV-2 infection or organizing pneumonia.

Minlong Zhang, Yinghua Guo, Cuiping Yang
DOI: 10.1002/rcr2.1389

We report a rare case of glandular papilloma in lung parenchyma. The glandular type of solitary respiratory papilloma (Glandular papilloma, GP) is the rarest type of these rare epithelial tumours. Most GP occurs in the proximal airways and is only rarely found in the lung parenchyma.